Results 111 to 120 of about 7,343,696 (302)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

OECD Energy Demand: Modelling Underlying Energy Demand Trends using the Structural Time Series Model [PDF]

Aggregate energy demand functions for 17 OECD countries are estimated with data for 1960-2003 using the Structural Time Series Model (STSM) thus allowing for a stochastic Underlying Energy Demand Trend (UEDT).
Arqam Al-Rabbaie, Lester C. Hunt
core  

Integrated climate resilient modelling of renewable energy transition in Nepal

There is a global consensus on the need for accelerating renewable energy transition. Developing countries have plentiful untapped feasible renewable energy which could be extremely valuable for the future.
Bhattarai, Utsav
core   +1 more source

The Energy Transition in the Age of Open Science: Call for Regional Modelling Solutions [PDF]

This work introduces a regional energy model, emphasizing the importance of localized approaches to sustainability. It highlights the significance of energy system models in guiding the energy transitions policies, underscoring the influence of open ...
Savoldi, Laura, Quatraro, Francesco, Amir Kavei, Farzaneh, Nicoli, Matteo   +3 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

High resolution modelling for performance assessment of future dwellings [PDF]

, 2014
In future low-energy buildings, electrical power and hot water use will feature prominently in the overall energy demand. Unlike space heating, these demand constituents are intermittent and vary rapidly over a few seconds.
Kelly, Nicolas, Samuel, Aizaz, Hand, Jon
core   +2 more sources

Techno-economic assessment of energy savings and CO2 emission reductions from replacing conventional HVAC systems with ground source heat pumps in Iran

Energy Conversion and Management: X
Energy policymakers must develop strategies to promote the adoption of newer and more sustainable systems. It has been demonstrated that ground source heat pump (GSHP) systems are significantly more environmentally friendly than conventional HVAC systems,
Younes Noorollahi, Mohammadreza Moshtaghi, Mohammad Golkar, Hamzeh Tahsinpour, Mahshid Noorollahi   +4 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Asymmetric Price Responses and the Underlying Energy Demand Trend: Are they Substitutes or Complements? Evidence from Modelling OECD Aggregate Energy Demand [PDF]

A number of energy demand studies have considered the importance of modelling Asymmetric Price Responses (APR), for example, the often-cited work of Gately and Huntington (2002). Griffin and Schulman (2005) questioned the asymmetric approach arguing that
Olutomi I Adeyemi, Guy Judge, David C Broadstock, Lester C Hunt, Mona Chitnis   +4 more
core