Results 41 to 50 of about 227,287 (266)
Open Geosciences, 2023 In response to the problems of lack of planning in management and high difficulty in law enforcement in urban and rural planning (URP for short here) and construction, this article proposes to apply the concept of low-carbon ecology (LCE) to URP and ...
Xiu Yujiao
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Environmental Research LettersClimate change is one of the biggest threats to global food security, with observed impacts already affecting agriculture. This study aims to systematize and analyze the observed biophysical impacts and their evolution in agriculture in Brazil. For this,
Ana Carolina Oliveira Fiorini +14 more
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Achieving the Renewable Energy Target for Jamaica [PDF]
Expert Journal of Economics, 2014 ieving the Renewable Energy Target for Jamaica Abstract: The high cost of energy in Jamaica, one of the highest in the Caribbean region, is usually cited as a hindrance to industrial development and efficiency, especially in the manufacturing sector ...
Abdullahi Olabode ABDULKADRI
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STRATEGIC ENVIRONMENTAL ASSESSMENT FOR PLANNING SUGARCANE EXPANSION: A FRAMEWORK PROPOSAL [PDF]
Ambiente & Sociedade, 2016 The Brazilian sugarcane industry has experienced a rapid expansion during the 2000s. The prediction of the sugarcane crop expansion in the coming decades raises controversy about social and environmental impacts, which are partially evaluated in the ...
AMARILIS LUCIA CASTELI FIGUEIREDO GALLARDO +2 more
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Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Challenges of Microgrids in Remote Communities: A STEEP Model Application
Energies, 2018 There is a growing interest in the application of microgrids around the world because of their potential for achieving a flexible, reliable, efficient and smart electrical grid system and supplying energy to off-grid communities, including their economic
Daniel Akinyele +2 more
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