Results 161 to 170 of about 9,551,205 (251)
Advanced Science, EarlyView.The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li +6 more
wiley +1 more source
Emerging Energy Trends: Regulatory Responses to Ontario’s Energy Future
, 2016 Produced by the Mowat Centre at the School of Public Policy and Governance, University of Toronto.On May 29, 2017, Mowat Energy hosted an international conference exploring the future of energy in Ontario.
Mowat Energy
core
Advanced Science, EarlyView.A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li +9 more
wiley +1 more source
Brave New World at the OEB: Policy Development and the Natural Gas Expansion Case
, 2016 Produced by the Mowat Centre at the School of Public Policy and Governance, University of Toronto.An ongoing Ontario Energy Board (OEB) proceeding offers timely insight into the role the Board sees itself playing in the implementation of government ...
Mowat Energy
core
A Thickness‐Invariant Origami Robot With Integrated Actuation and Multimodal Locomotion
Advanced Science, EarlyView.A thickness‐invariant variation on the Yoshimura origami pattern is used as the basis of a robot, allowing power, actuation, and control systems to be embedded within the thickened panels of the pattern. The robot uses multiple kinematic branches to achieve distinct modes of locomotion, such as walking, running, galloping, and turning. ABSTRACT Origami
Davis Wing +4 more
wiley +1 more source
Advanced Science, EarlyView.A thermochemically engineered core–shell Si architecture is developed through the controlled evolution of a SWCNT‐coated Mg2Si precursor. The process simultaneously generates a nanoporous Si shell for strain accommodation and Li+ transport, a chemically anchored SiC interfacial layer for robust mechanical and electrical coupling, and a Mg‐containing Si
Dong Gyun Hong +11 more
wiley +1 more source
Advanced Science, EarlyView.A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu +13 more
wiley +1 more source
Energy market reforms to facilitate new technologies
, 2016 The Clean Energy Council believes energy market reform should prioritise the following initiatives: • Accelerate the transition to a cleaner energy sector by overcoming conflict between institutions and ensuring that the National Energy Objectives ...
Clean Energy Council
core
Advanced Science, EarlyView.Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee +5 more
wiley +1 more source
Towards a Compositional Framework for Describing Human Phenotypes
Advanced Science, EarlyView.The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu +11 more
wiley +1 more source