Results 81 to 90 of about 2,653,570 (338)

Energy resolution and linearity of XENON1T in the MeV energy range

open access: yesEuropean Physical Journal C: Particles and Fields, 2020
Xenon dual-phase time projection chambers designed to search for weakly interacting massive particles have so far shown a relative energy resolution which degrades with energy above $$\sim $$ ∼ 200 keV due to the saturation effects.
E. Aprile   +141 more
doaj   +1 more source

Phenomenological model for predicting the energy resolution of neutron-damaged coaxial HPGe detectors

open access: yes, 2011
The peak energy resolution of germanium detectors deteriorates with increasing neutron fluence. This is due to hole capture at neutron-created defects in the crystal which prevents the full energy of the gamma-ray from being recorded by the detector.
Caffrey, A. J.   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Induced Charge Fluctuations in Semiconductor Detectors with a Cylindrical Geometry

open access: yesEPJ Web of Conferences, 2018
Now, compound semiconductors are very appealing for hard X-ray room-temperature detectors for medical and astrophysical applications. Despite the attractive properties of compound semiconductors, such as high atomic number, high density, wide band gap ...
Samedov Victor V.
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Development and Performance Characteristics of Personal Gamma Spectrometer for Radiation Monitoring Applications

open access: yesSensors, 2016
In this study, a personal gamma (γ) spectrometer was developed for use in applications in various fields, such as homeland security and environmental radiation monitoring systems.
Hye Min Park, Koan Sik Joo
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Flat-topped cusp-like shaper algorithm based on the unfolding-synthesis technique

open access: yesHe jishu
BackgroundThe unfolding-synthesis technique is commonly used in digital pulse processing systems for nuclear radiation measurements.PurposeThis study aims to propose a novel flat-topped widened peak-shaping algorithm based on the pulse unfolding ...
LAN Jimei   +5 more
doaj   +1 more source

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