Results 41 to 50 of about 3,323,356 (286)

Application of systems analysis for reconstruction of the model of cross-border resource flows and collaboration in R&D under the influence of sanctions

Модернизация, инновация, развитие, 2023
Purpose: of the article is to form assessments based on system analysis to determine with whom Russia needs to interact in a situation of severe sanctions both in an open economy and whithin the framework of an open innovation model.Methods: the ...
A. A. Nikonova
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Accessibility of the resources of near Earth space using multi-impulse transfers [PDF]

, 2010
Most future concepts for exploration and exploitation of space require a large initial mass in low Earth orbit. Delivering this mass requires overcoming Earth's natural gravity well, which imposes a distinct obstacle to space-faring.
Bonanno C., Jack G.H., Kawaguchi J., Mckay M. F., Opik E. J., Ross S.D., Stuart J. S.   +6 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

An assessement of global energy resource economic potentials [PDF]

, 2012
This paper presents an assessment of global economic energy potentials for all major natural energy resources. This work is based on both an extensive literature review and calculations based onto natural resource assessment data. Economic potentials are
Mercure, JF, Salas, P
core   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Evaluating the Energy Resources and Environmental Impacts for Blueberry Packaging Materials with a Focus on End-of-Life Scenarios

Energies
Because of their many health benefits, blueberries are highly sought after as superfoods. There are also ongoing initiatives to enhance sustainability in blueberry packaging by selecting appropriate materials.
Viktoria Mannheim, Ulvi Moor, Liina Laumets, Klára Tóthné Szita   +3 more
doaj   +1 more source

Substitution of labour and energy in agriculture and options for growth [PDF]

, 1975
Viewed from the technical angle, labour and energy may be considered the basic resources for production. Methods to compute the requirement of energy and labour for the production processes from raw material to the product at the farm gate are discussed.
Wit, C.T., de
core   +3 more sources