Results 71 to 80 of about 10,501,208 (305)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Policy analysis for energy efficiency in the built environment in Spain [PDF]

, 2013
Energy efficiency is considered one of the most cost effective ways to enhance security of energy supply and reduce greenhouse gas emissions. According to Europe's Energy Efficiency Plan, the biggest energy savings potential in the EU lies in the built ...
Gideon van Toledo, Harmsen, Robert, Jessica Yearwood Travezan, Energy, Resources & Technological Change, Energy and Resources, Robert Harmsen, Yearwood Travezan, Jessica, van Toledo, Gideon   +7 more
core   +1 more source

RULE OF LAW, SECURITY AND SUSTAINABLE DEVELOPMENT IN ROMANIA [PDF]

Annals: Series on Military Sciences, 2014
Threats, risks and perils we are facing today are complex and atypical. The importance of limited natural resources is put under debate more than anytime before by great world actors through new security concepts.
Mirela PUSCASU
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Techno-economic assessment of micro-algae as feedstock for renewable bio-energy production [PDF]

, 2013
This paper determines the energy consumption ratio and overall bio-energy production costs of microalgae cultivation, harvesting and conversion to secondary energy carriers, thus helping to clarify future perspectives of micro-algae production for energy
Jonker, J.G.G., Faaij, A.P.C., Energy System Analysis, Energy and Resources   +3 more
core   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Linking Historic Developments and Future Scenarios of Industrial Energy Use in the Netherlands between 1993 and 2040 [PDF]

, 2013
Monitoring energy efficiency improvements is essential for policy evaluation and for future policy making. We estimate the annual energy efficiency improvements achieved in six Dutch industry sectors between 1993 and 2008 by using a bottom-up model. This
Wetzels, Wouter, Saygin, D., Patel, M.K., Saygin, Deger, Energy, Resources & Technological Change, Energy and Resources, Worrell, Ernst, Sub IMW Energy & Resources Externen, Worrell, E., Wetzels, W., Patel, Martin   +10 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

NEW GEOPOLITICS OF THE ARCTIC: U.S. STRATEGY IN A MULTIPOLAR WORLD [PDF]

Научно-аналитический вестник Института Европы РАН
As the international system transitions to multipolarity, the United States and its Western allies are developing new strategies to maintain their influence in the world.
Zafar Javed
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source