Results 61 to 70 of about 5,903,017 (263)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Quantum Computing Method for AC Power Flow with Residual-Controlled Dynamic Precision

Entropy
To address the amplification of correction errors caused by an ill-conditioned AC power-flow Jacobian under heavily loaded operating conditions, as well as the excessive circuit depth associated with a fixed quantum-solution accuracy, this paper proposes
Mengbo Yan, Dabo Zhang, Kanghai Yang, Yuan Cao   +3 more
doaj   +1 more source

Optimal layout of pressure monitoring points in water supply network based on Optics

E3S Web of Conferences, 2019
It is necessary to monitor the pressure in the networks in real time, when we face the problem of pipe burst and leakage in urban water supply network. Therefore, it is particularly important to arrange pressure monitoring points in appropriate places in
Xie ChenLei, Fang QianSheng, Zhang HongYan, Zhang JiXin   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cross-attention-based hybrid feature fusion network for state-of-health estimation of lithium-ion batteries

Scientific Reports
Estimating the state of health (SOH) of lithium-ion batteries (LIBs) is crucial in a battery management system. To improve the accuracy of SOH estimation, a new method that combines a Gramian angle field (GAF) and multi–model fusion is proposed.
Yang Zhao, Limin Geng, Weijia Meng, Jinhao Meng, Chunling Wu, Xunquan Hu, Zeyu Du   +6 more
doaj   +1 more source

Investigation on combustion and emission characteristics of diesel polyoxymethylene dimethyl ethers blend fuels with exhaust gas recirculation and double injection strategy

Journal of Traffic and Transportation Engineering (English ed. Online)
As a kind of renewable and high oxygen content fuel, polyoxymethylene dimethyl ether (PODE) can be added in diesel to realize energy saving and emissions reduction.
Xin Su, Rui Su, Nan Gao, Hao Chen, Zhenhua Ji, Hongming Xu, Biao Wang   +6 more
doaj   +1 more source

Time-Saving Innovations, Time Allocation, and Energy Use: Evidence from Canadian Households [PDF]

Time and energy are major inputs into the production of household goods and services. The introduction of time-saving innovations allows households to change their activity patterns and to reallocate their time across competing activities.
Young, Denise, Brencic, Vera
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source