Results 61 to 70 of about 899,380 (309)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Creation of Nanowires for Energy Saving Applications [PDF]

open access: yes, 2012
Color poster with text, images, and graphs.With nearly everything we use in modern society being electronic, energy consumption is a high cost factor. Most electronics draw small amounts of power when plugged in.
Ives, Caramon   +2 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Black-Box Behavioral Modeling of Voltage and Frequency Response Characteristic for Islanded Microgrid

open access: yesEnergies, 2019
The voltage and frequency response model of microgrid is significant for its application in the design of secondary voltage frequency controller and system stability analysis. However, most models developed for this aspect are complex in structure due to
Yong Shi   +5 more
doaj   +1 more source

Implementing energy saving algorithms for Ethernet link aggregates with ONOS

open access: yes, 2018
During the last few years, there has been plenty of research for reducing energy consumption in telecommunication infrastructure. However, many of the proposals remain unim-plemented due to the lack of flexibility in legacy networks.
Ferreiro, Pablo Fondo   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Investigation on combustion and emission characteristics of diesel polyoxymethylene dimethyl ethers blend fuels with exhaust gas recirculation and double injection strategy

open access: yesJournal of Traffic and Transportation Engineering (English ed. Online)
As a kind of renewable and high oxygen content fuel, polyoxymethylene dimethyl ether (PODE) can be added in diesel to realize energy saving and emissions reduction.
Xin Su   +6 more
doaj   +1 more source

Optimal layout of pressure monitoring points in water supply network based on Optics

open access: yesE3S Web of Conferences, 2019
It is necessary to monitor the pressure in the networks in real time, when we face the problem of pipe burst and leakage in urban water supply network. Therefore, it is particularly important to arrange pressure monitoring points in appropriate places in
Xie ChenLei   +3 more
doaj   +1 more source

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