Results 121 to 130 of about 563,564 (315)

A Data Prediction and Physical Simulation Coupled Method for Quantifying Building Adjustable Margin

Buildings
Buildings account for nearly 32% of global energy consumption and serve as key demand-side flexibility resources in power systems with high renewable penetration.
Bangpeng Xie, Liting Zhang, Wenkai Zhao, Yiming Yuan, Xiaoyi Chen, Xiao Luo, Chaoran Fu, Jiayu Wang, Fanyue Qian, Yongwen Yang, Sen Lin   +10 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A field test of compact active transponders for InSAR geodesy

Journal of Geodetic Science
Compact active transponders (CATs) – also termed electronic corner reflectors – are compact electronic devices designed to receive, actively amplify and re-transmit a radar signal, e.g. a C-band radar signal received from a Sentinel-1 satellite. CATs can
Meister A., Balasis-Levinsen J., Keller K., Pedersen M. R. V., Merryman Boncori J. P., Jensen M.   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Bioenergy potentials from forestry in 2050 : An assessment of the drivers that determine the potentials

, 2007
The purpose of this study was to evaluate the global energy production potential of woody biomass from forestry for the year 2050 using a bottom-up analysis of key factors.
Faaij, A.P.C., Smeets, E.M.W., Options for a sustainable energy supply, Dep Scheikunde   +3 more
core  

Experimental investigation of hydrogen production performance of PEM electrolyze

Scientific Reports
As global awareness of environmental protection increases, hydrogen is seen as a promising solution due to its high energy density and zero-emission combustion. The PEM electrolyze combined with renewable energy power generation is an effective method to
Chen Aijun, Pan Jun, Zhang Hang, Feng Keying, Liu Xubin   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Renewable Energy Supply and Risk in Global Banking

, 2023
Financial and economic concerns are paramount for the international banking industry to continue supporting and investing in the global renewable energy supply system.
Choudhury, Tonmoy, Hassan, Mohammad Kabir, Djajadikerta, Hadrian, Hasan, Fakhrul, Sarker, Tapan, Boubaker, Sabri, Kamran, Muhammad   +6 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source