Results 31 to 40 of about 379,777 (267)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Fatigue crack propagation analysis using XFEM for cladded C(T) specimens and its validation

Mechanical Engineering Journal
To investigate the crack growth behavior in a cladded structure, a numerical simulation method based on the extended finite element method (XFEM) was developed.
Yanlong LI, Toshio NAGASHIMA, Masaki NAGAI, Tomoki SHINKO, Naoki MIURA   +4 more
doaj   +1 more source

Energy Transfer Using Unitary Transformations [PDF]

Entropy, 2013
We study the unitary time evolution of a simple quantum Hamiltonian describing two harmonic oscillators coupled via a three-level system. The latter acts as an engine transferring energy from one oscillator to the other and is driven in a cyclic manner by time-dependent external fields.
Winny O'Kelly de Galway, Jan Naudts
openaire   +6 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Legitimacy and accountability in the governance of sustainable energy transitions

Global Transitions, 2020
How can we enable equitable decarbonisation? There is a wide gap between power to make transformative decisions, on the one hand, and agency on the part of those affected by climate change, on the other.
Siddharth Sareen, Håvard Haarstad
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Assessment of Grid and System Supportability Based on Spatio-Temporal Conditions—Novel Key Performance Indicators for Energy System Evaluation

Energies
The energy transition introduces new technical standards, laws and regulations regarding the stability and reliability of energy grids and systems. Due to the non-existence of a measuring standard, key performance indicators (KPIs) were developed to ...
Heiko Waurisch, Nick von Bargen, Nico Ploczicki, Bente Ralfs, Berit Elsner, Reiner Schütt, Nassipkul Dyussembekova   +6 more
doaj   +1 more source

Using collaborative hackathons to coproduce knowledge on local climate adaptation governance

Current Research in Environmental Sustainability, 2021
While coproduction of knowledge is growing in popularity in social sciences, and especially climate change research, we still need to better understand how to coproduce climate knowledge.
Hanna Kvamsås, Simon Neby, Håvard Haarstad, Mathew Stiller-Reeve, Jesse Schrage   +4 more
doaj   +1 more source