Results 71 to 80 of about 645,257 (264)
Abnormal band bowing effects in phase instability crossover region of GaSe1-x Te x nanomaterials
Nature Communications, 2018 Alloys of two-dimensional materials normally occur when two components crystallize in the same phase. Here, the authors observe an anomalous phase instability, accompanied by a band bowing effect, in GaSe1-x Te x alloys on GaAs(111).
Hui Cai +6 more
doaj +1 more source
Development Path of China’s Ports Under Carbon Peaking and Neutrality Goals [PDF]
E3S Web of ConferencesCarbon peaking and neutrality goals constitute the major strategic decisions in ecological civilization construction in China. The port industry is characterized by intense carbon emissions, strong regional aggregation, and large emissions of single-used
Li Luning +3 more
doaj +1 more source
The energy impact of adaptive cruise control in real-world highway multiple-car-following scenarios
European Transport Research Review, 2020 Background Surging acceptance of adaptive cruise control (ACC) across the globe is further escalating concerns over its energy impact. Two questions have directed much of this project: how to distinguish ACC driving behaviour from that of the human ...
Yinglong He +5 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Energy transport through Earth’s plasma sheet in 3-D
Frontiers in Astronomy and Space SciencesA statistical analysis of energy transport through Earth’s plasma sheet is performed using 6 years of Magnetospheric Multi-Scale (MMS) mission observations. The analysis entails a complete decomposition of the contributions to transport including the ion
K. C. Barik, C. C. Chaston
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Applied Sciences, 2019 Interoperability is a challenge for the realisation of smart grids. In this work, we apply the methodology for interoperability testing and the design of experiments developed at the Smart Grids Interoperability Laboratory of the Joint Research Centre of
Nikoleta Andreadou +3 more
doaj +1 more source