Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh +5 more
wiley +1 more source
High Health Care Utilization Preceding Diagnosis With Juvenile Idiopathic Arthritis
Objective Although early diagnosis improves long‐term outcomes, patients with juvenile idiopathic arthritis (JIA) often experience prolonged, circuitous paths to diagnosis. To inform diagnostic improvement, we sought to characterize health care utilization in the year preceding diagnosis. Methods We identified 10,021 patients with an incident diagnosis
Anna Costello +5 more
wiley +1 more source
[Determinants of healthcare-seeking delay in women with acute coronary syndrome]. [PDF]
Parellada-Vendrell M +5 more
europepmc +1 more source
Objective To support high‐quality, patient‐centered care for systemic lupus erythematosus (SLE), the American College of Rheumatology (ACR) developed evidence‐based measures incorporating clinical and patient‐reported outcome measures (PROMs). Using the Consolidated Framework for Implementation Research (CFIR), we conducted semistructured interviews ...
Catherine Nasrallah +13 more
wiley +1 more source
Is mental health in Colombia a right or a privilege? [PDF]
Escobar M +7 more
europepmc +1 more source
Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han +11 more
wiley +1 more source
[High diagnostic discrepancy in infectious diseases detected by autopsy]. [PDF]
Cisneros-Aréchiga AG +4 more
europepmc +1 more source
Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau‐PET.
Isabella Bizzi +83 more
wiley +1 more source
[Advanced chronic kidney disease and end-stage kidney disease in Latin America: Gaps in continuity of care, the strategic role of kidney transplantation, and challenges for health governanceDoença renal crônica avançada e terminal na América Latina: lacunas no continuum de cuidados, papel estratégico do transplante renal e desafios para a governança em saúde]. [PDF]
Grinblat N, Menjívar A, Beltrán M.
europepmc +1 more source

