Results 31 to 40 of about 1,076,986 (335)

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Impact of migration on the occurrence of new cases of Chagas disease in Buenos Aires city, Argentina [PDF]

, 2013
Chagas disease, also known as American Trypanosomiasis, is endemic in the Americas, especially Central and South America. Chagas disease is a zoonotic disease caused by the parasite Trypanosoma cruzi.
Altcheh, Jaime Marcelo, Ballering, Griselda, Berenstein, Ada, Biancardi, Miguel Angel, Espejo Cozzi, Andres, Freillij, Hector, Garcia Bournissen, Facundo, Hernandez, Susana, Moroni, Samanta, Moscatelli, Guillermo, Schwarcz, Marta, Siniawski, Susana, Tarlovsky, Ana   +12 more
core   +2 more sources

Histiocitosis congénita de células de Langerhans

Biomédica: revista del Instituto Nacional de Salud, 2020
La histiocitosis de células de Langerhans es una enfermedad poco frecuente, cuyas manifestaciones clínicas pueden aparecer en el periodo neonatal y varían desde lesiones óseas aisladas hasta un compromiso sistémico.
Katherine Barrios, Oscar Patiño, Nelson Muñoz, Carlos Moneriz   +3 more
doaj   +1 more source

Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières [PDF]

, 2009
BACKGROUND: Chagas disease (American trypanosomiasis) is a zoonotic or anthropozoonotic disease caused by the parasite Trypanosoma cruzi. Predominantly affecting populations in poor areas of Latin America, medical care for this neglected disease is often
A Valencia, AG Schijman, AL de Andrade, AO Luquetti, CD Fernandes, E Segura, F Guhl, Fernando Parreño, G Guillén, GA Schmuñis, JHF Remme, JP Chippaux, JR Cançado, JR Coura, JR Coura, L Villa, Laurence Flevaud, M Zaidenberg, M. Angeles Lima, ML Streiger, Oliver Yun, P Roddy, Paul Roddy, Pedro Albajar Viñas, Pedro Pablo Palma, R Tarleton, RE Gürtler, RE Gürtler, Ricardo E. Gürtler, S Sosa Estani, S Sosa-Estani, S Sosa-Estani, S Sosa-Estani, Sandra Castillo, Tom Ellman, Wilma Chambi   +35 more
core   +4 more sources

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source

Medicine 5th course student’s attitudes towards mental health [PDF]

, 2012
Introducción. El estigma social que persiste hacia la enfermedad mental puede estar presente en los estudiantes de medicina e impactar en la forma de considerar ésta y la psiquiatría como especialidad. Objetivo.
Caballero, Luis, Failde Martínez, Inmaculada, Gilaberte, Inmaculada, Salazar Couso, Alejandro   +3 more
core   +2 more sources

Development and evaluation of a duplex TaqMan qPCR assay for detection and quantification of Trypanosoma cruzi infection in domestic and sylvatic reservoir hosts

Parasites & Vectors, 2019
Background A question of epidemiological relevance in Chagas disease studies is to understand Trypanosoma cruzi transmission cycles and trace the origins of (re)emerging cases in areas under vector or disease surveillance.
Diana P. Wehrendt, Andrea Gómez-Bravo, Juan C. Ramirez, Carolina Cura, Angélica Pech-May, Janine M. Ramsey, Marcelo Abril, Felipe Guhl, Alejandro G. Schijman   +8 more
doaj   +1 more source

Ecologia domestica de la tripanosomiasis americana: perfil alimentario del triatoma infestans en un area rural de la província de Santiago del Estero, Argentina

Revista da Sociedade Brasileira de Medicina Tropical, 1987
Se describen los resultados entomológicos de un estúdio sobre transmiswn del Tripanosoma cruzi realizado en un caserío rural de Argentina. Se determino la prevalencia de infección elperfil alimentario de los Triatoma infestans domiciliados ...
Cristina Wisnivesky-Colli, A. M. Ruiz, O. Ledesma, R. E. Gütler, Marta Lauricella, D.O. Salomon, Nora Solarz, Elsa L. Segura   +7 more
doaj   +1 more source