Results 31 to 40 of about 315,543 (357)

Enfermedad de Fabry. Una enfermedad renal crónica

RECIMUNDO, 2022
La enfermedad de Fabry pertenece al grupo de las enfermedades lisosomales, de patologías poco frecuentes de origen genético, debidas a mutaciones patogénicas en genes que codifican para proteínas, asociadas a la función de los lisosomas. La metodología utilizada para el presente trabajo de investigación, se enmarca dentro de una revisión bibliográfica ...
Silvia Marcela Guaigua López, Cristian Alejandro Guamán Castillo, Matías Sebastián Zambrano Sangurima, Adrian David Campoverde Cárdenas   +3 more
openaire   +1 more source

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Diagnóstico y tratamiento de la enfermedad inflamatoria intestinal: Primer Consenso Latinoamericano de la Pan American Crohn's and Colitis Organisation

Revista de Gastroenterología de México, 2017
La incidencia y la prevalencia de la enfermedad inflamatoria intestinal (EII) se han incrementado en los últimos años en varios países de Latinoamérica. Existe una necesidad de concientizar a gastroenterólogos y a la población en general para poder tener
J.K. Yamamoto-Furusho, F. Bosques-Padilla, J. de-Paula, M.T. Galiano, P. Ibañez, F. Juliao, P.G. Kotze, J.L. Rocha, F. Steinwurz, G. Veitia, C. Zaltman   +10 more
doaj   +1 more source

Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit‐to‐stand (STS), and evaluated their abilities to predict poor health outcomes.
Kylie E. Riggles, Hannah F. Brubeck, Adrienne D. Tanus, Courtney N. Loecker, Punyasha Roul, Bryant R. England, Elizabeth R. Wahl, James S. Andrews, Namrata Singh, Joshua F. Baker, Patricia P. Katz, Dolores M. Shoback, Jose M. Garcia, Ariela R. Orkaby, Katherine D. Wysham   +14 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Development and evaluation of a duplex TaqMan qPCR assay for detection and quantification of Trypanosoma cruzi infection in domestic and sylvatic reservoir hosts

Parasites & Vectors, 2019
Background A question of epidemiological relevance in Chagas disease studies is to understand Trypanosoma cruzi transmission cycles and trace the origins of (re)emerging cases in areas under vector or disease surveillance.
Diana P. Wehrendt, Andrea Gómez-Bravo, Juan C. Ramirez, Carolina Cura, Angélica Pech-May, Janine M. Ramsey, Marcelo Abril, Felipe Guhl, Alejandro G. Schijman   +8 more
doaj   +1 more source

Docencia-servicio: responsabilidad social en la formación del talento humano en salud en Colombia

Educación Médica, 2018
Resumen: El objetivo fue analizar la evidencia científica sobre la relación docencia-servicio como responsabilidad social en la formación de talento humano en salud en Colombia. Se realizó una revisión documental de publicaciones en revistas científicas,
Consuelo Vélez Álvarez, Claudia Patricia Jaramillo Ángel, Alexandra Giraldo Osorio   +2 more
doaj   +1 more source

Enfermedad de Hirschsprung. Informe de caso

, 2022
La enfermedad de Hirschsprung es una dolencia congénita caracterizada por la falta de células ganglionares en el plexo mientérico o plexo muscular y el plexo submu- coso o de Meissner del recto y otros segmentos del co- lon en dirección proximal. Provoca
Gamboa-Céspedes, Mariana Estrella, Domínguez-Santiesteban, Sergio Alejandro, Martínez-Díaz, Isleisy, Pose-Ramos, Darián De Jesús   +3 more
core   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source