Results 51 to 60 of about 409,064 (196)
Se realizó un estudio observacional, prospectivo y descriptivo, con el objetivo de caracterizar el comportamiento de la enfermedad cerebrovascular de la población anciana, perteneciente a tres consultorios del Equipo Básico # 3, del Policlínico ...
Damarys Hernández Suárez +3 more
doaj
Enfermedad cerebrovascular y trombofilia
La trombofilia es una condicion que se debe tener presente en las enfermedades cerebrovasculares (ECV) isquemicas. Si bien se considera que es la causa de un bajo porcentaje de ellas, dada la alta incidencia de las ECV isquemicas, el numero de pacientes con esta condicion pasa a ser significativo.
openaire +2 more sources
Abstract INTRODUCTION Sleep and circadian rest–activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR patterns across the DS‐associated AD continuum remain uncharacterized. METHODS We analyzed 7‐day wrist actigraphy in 140 adults
Sandra Giménez +26 more
wiley +1 more source
Abstract INTRODUCTION This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker of microvascular white matter (WM) injury, in sporadic Alzheimer's disease (sAD) and Down syndrome (DS)–associated AD (DSAD).
Alejandra O. Morcillo‐Nieto +27 more
wiley +1 more source
Introducción: Con la transición demográfica y el aumento de la población mundial, el número de muertes por enfermedad isquémica cardiaca (EIC) y enfermedad cerebrovascular (ECV) ha ido en aumento en la última década.
María C. Valencia-Mendoza +2 more
doaj +1 more source
In vivo mapping of cortical amyloid beta‐myelin coupling in preclinical Alzheimer's disease
Abstract INTRODUCTION Accumulating evidence suggests that amyloid‐β (Aβ) preferentially deposits in poorly myelinated cortical regions and may interfere with remyelination. We hypothesized that this vulnerability would manifest as altered Aβ–myelin coupling in preclinical Alzheimer's disease (AD).
Mercedes Atienza, Jose L. Cantero
wiley +1 more source
Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants
Abstract INTRODUCTION The sortilin‐related receptor (SORL1) directs APP and Aβ trafficking within the retromer pathway. Cleavage at the cell surface releases soluble SORL1 (sSORL1) into cerebrospinal fluid (CSF). We examined whether CSF‐sSORL1 can serve as an in vivo marker of genetically impaired SORL1.
Matthijs W. J. de Waal +24 more
wiley +1 more source
Factors impacting survival in individuals with Down syndrome‐associated Alzheimer's disease
Abstract INTRODUCTION Adults with Down syndrome (DS) are at high risk for Alzheimer's disease (AD), the leading cause of death in this population. Survival in DS after AD diagnosis appears shorter than in sporadic AD; however, the factors influencing survival remain poorly understood.
Bessy Benejam +24 more
wiley +1 more source
Abstract INTRODUCTION White matter hyperintensities (WMH) are common in Down syndrome (DS), yet their longitudinal evolution and associations with Alzheimer's disease (AD) remain unclear. METHODS Longitudinal MRI study, including 80 DS adults and 53 euploid controls. WMH were segmented on serial FLAIR using a longitudinal pipeline.
Alejandra O. Morcillo‐Nieto +24 more
wiley +1 more source
Aim The aim is to assess the exposure to neuroendovascular intervention and perceptions among trainees in Latin America. Methods A descriptive and cross‐sectional study was conducted from October to December 2024 and was aimed at neurology residents and/or fellows in Latin American hospitals.
Miguel A. Vences +4 more
wiley +1 more source

