Results 81 to 90 of about 3,417 (205)

Modelamiento matemático de la enfermedad de Legg-Calvé-Perthes Mathematical modeling of Legg-Calvé-Perthes disease

open access: yesRevista Cubana de Investigaciones Biomédicas, 2011
La enfermedad de Legg-Calvé-Perthes es un desorden caracterizado por la necrosis avascular de la cabeza femoral del esqueleto en desarrollo. Aunque la enfermedad fue descrita hace un siglo, aún existe gran controversia respecto a su etiología y al ...
Alejandro Gamboa Márquez   +1 more
doaj  

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise   +2 more
wiley   +1 more source

Enfermedad de Still [PDF]

open access: yesRevista chilena de pediatría, 1943
openaire   +2 more sources

Validation of an UHPLC–MS/MS Assay for the Quantification of Isoniazid and Four Major Metabolites in Human Plasma

open access: yesBiomedical Chromatography, Volume 40, Issue 9, September 2026.
ABSTRACT Isoniazid (INH) is a key component of tuberculosis treatment regimens but is also associated with hepatotoxicity. This toxicity is mediated in part by its metabolites, but some degrade rapidly in plasma. A rapid freeze/thaw process with a methanol protein precipitation extraction was developed to slow the rapid degradation of acetylisoniazid ...
David Nerguizian   +6 more
wiley   +1 more source

Fiebre de origen desconocido: revisión de 105 pacientes

open access: yesRevista Cubana de Medicina, 1995
Se estudiaron 105 pacientes con fiebre de origen desconocido, ingresados en el Hospital "Hermanos Ameijeiras" en el período 1988-1992. Las principales causas fueron las neoplasias, sobre todo las hematológicas (linfomas), seguidas por las enfermedades ...
Luis Alberto Cruz Peña   +2 more
doaj  

Feathers and flu: identifying data gaps in avian influenza host dynamics to prioritize wildlife conservation Plumas y gripe: identificación de datos faltantes en la dinámica de hospedadores de la influenza aviar para priorizar la conservación de la vida silvestre

open access: yesWildlife Monographs, Volume 225, Issue 1, September 2026.
We describe the host response continuum for highly pathogenic avian influenza viruses (HPAIV), including the continuum of host responses to HPAIV infection and exposure based on the primary axis of host competence, ability to infect other hosts, and host vulnerability.
Johanna A. Harvey   +9 more
wiley   +1 more source

Decoding the allosteric grammar of protein kinases: A dual‐stream framework integrating protein language models and energy landscape frustration analysis

open access: yesProtein Science, Volume 35, Issue 8, August 2026.
Abstract The spatial and energetic encoding of allosteric regulatory sites remains a major challenge in structural biology, frequently representing a “blind spot” for sequence‐based artificial intelligence (AI) models. We present a protein language model (PLM)‐guided approach complemented by the energy landscape frustration analysis as a dual‐stream ...
Will Gatlin   +8 more
wiley   +1 more source

Pocket restraints guided by B‐cell epitope prediction improve Chai‐1 antibody–antigen structure modeling

open access: yesProtein Science, Volume 35, Issue 8, August 2026.
Abstract The accurate prediction of antibody–antigen (AbAg) complexes is a key challenge for computational immunology, with applications in therapeutic antibody design and diagnostics. Current deep learning methods have the potential to generate high‐confidence AbAg structures.
Joakim Nøddeskov Clifford   +1 more
wiley   +1 more source

Enfermedad inmunoproliferativa del intestino delgado

open access: yesRevista Cubana de Medicina, 1996
Se presenta el caso de una paciente con una enfermedad inmunoproliferativa de intestino delgado, tipo enfermedad de cadenas alfa, con el objetivo de dar a conocer una entidad infrecuente, que constituye el segundo caso en Cuba.
Alfredo Vázquez Vigoa   +4 more
doaj   +2 more sources

Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 4836-4854, August 2026.
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu   +9 more
wiley   +1 more source

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