Results 21 to 30 of about 490 (131)

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source

Skin Abnormalities at Checkpoint Inhibitor Therapy Initiation Are Associated With Skin Rash Development in Oncology Patients

Allergy, EarlyView.
Skin tape strip lipidomic analysis revealed preexisting skin barrier lipid abnormalities at day 0 that were further exacerbated after 6 weeks of CPI treatment. Significant changes in skin (but not plasma) proinflammatory cytokines were identified in future ircAE patients after 6 weeks of CPI immunotherapy.
Taras Lyubchenko, Evgeny Berdyshev, Ryan M. Weight, Olivia Xiao, Neil J. Shah, Alina Markova, Mario E. Lacouture, Jeffrey A. Kern, Elena Goleva, Donald Y. M. Leung   +9 more
wiley   +1 more source

Monitoring wildlife health for diseases with visible signs by integrating camera traps with marked individuals

Conservation Biology, EarlyView.
Abstract Monitoring wildlife health is essential for conservation and management, wildlife and livestock welfare, and public health in a One Health framework. Yet, wildlife health monitoring often requires long‐term fieldwork and intensive sampling, which can be costly or logistically challenging, especially for remote, rare, or elusive populations. To
Jonathan Tichon, Roi Lapid, Roni King, Elyasaf Freiman, Orr Spiegel, Erez Baruchi, Aviam Atar, Shirli Bar‐David, David Saltz   +8 more
wiley   +1 more source

El derecho a morir de forma digna, un estudio de las directrices anticipadas en el estado de Jalisco, México

Trayectorias Humanas Trascontinentales
Las personas tenemos derecho a la protección de nuestra salud, la cual es uno de los bienes más preciados; promoverla, protegerla y en caso de enfermedad recuperarla es una de las tareas cotidianas de forma individual pero también es una tarea de Estado.
Alma Jéssica VELÁZQUEZ GALLARDO
doaj   +1 more source

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

The FEBS Journal, EarlyView.
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe, Jiawei Xing, Xiansha Xiao, John A. Buglino, Huilin Li, Igor B. Zhulin, Michael S. Glickman   +6 more
wiley   +1 more source

Compromiso renal en un paciente con esclerosis tuberosa

Revista Universitas Medica, 2007
La esclerosis tuberosa es una enfermedad hereditaria, autosómica dominante y multisistémica, que cursa generalmente con crisis de epilepsia, retraso mental y tumores benignos en el cerebro y en otros órganos vitales como riñones, corazón, ojos, pulmones ...
Adriana Moreno Daza, Paola García Padilla, Roberto D'Achiardi Rey   +2 more
doaj  

Dolutegravir population pharmacokinetics in racially, sex‐ and age‐diverse and antiretroviral therapy‐experienced adults with HIV in the United States

HIV Medicine, EarlyView.
Abstract Objectives Dolutegravir (DTG) has been associated with weight gain in women with HIV, Black people with HIV and people with HIV60 years. This study aimed to characterise DTG population pharmacokinetics (PopPK) in a diverse population including these sub‐populations.
Adrian Khoei, Andrew Edmonds, Yen Chang, Catalina Ramirez, Mackenzie Vogan, Amanda Poliseno, Steven Wolinsky, Ken Ho, Todd T. Brown, Joseph B. Margolick, Jacquett Batson, Jennifer Hoffmann, Mark A. Marzinke, Mirjam‐Colette Kempf, Maria L. Alcaide, Joffi Effoe, Cecile D. Lahiri, Igho Ofotokun, Anandi N. Sheth, Stephen Gange, Audrey L. French, Bani Tamraz, Bradley E. Aouizerat, Phyllis C. Tien, Seble G. Kassaye, Jack DeHovitz, Kathryn Anastos, Kara W. Chew, Michelle Floris‐Moore, Julie B. Dumond   +29 more
wiley   +1 more source

El enfermo cardiovascular, el cardiólogo y la boiética.

Revista Cubana de Cardiología y Cirugía Cardiovascular, 2012
Introducción   Objetivo   Método   Desarrollo   Conclusiones   La cultura médica contemporánea enfrenta la lógica que impone el desarrollotecnológico. Los principios descritos facilitan la toma de decisiones del médico enfrentado a un dilema ético en el ...
Antonio Castillo Guzmán, Carmen Arocha Mariño, Ivette Castillo Arocha, Michel E. Cueto Cañabate, Nurys B. Armas Rojas, Omar González Grek   +5 more
doaj  

A Single‐Nucleotide Substitution Generates a de Novo Promoter That Activates a Latent Metabolic Bypass in Escherichia coli

Molecular Microbiology, EarlyView.
A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo, Qi Zou, Jilong Qin, Makrina Totsika, Yaoqin Hong, John E. Cronan   +5 more
wiley   +1 more source

VALORACIÓN NUTRICIONAL EN PACIENTES CON ENFERMEDAD RENAL CRÓNICA, ESTADIO 5D, QUE REALIZAN HEMODIAFILTRACIÓN Y HEMODIÁLISIS

Revistas Argentina de Medicina, 2023
Resumen: Existen múltiples causas de desnutrición proteico-energética en pacientes con enfermedad renal crónica (ERC) avanzada. Objetivos. En este estudio se pretende determinar si existe asociación entre el estado nutricional del paciente con ERC ...
Maria Amelia Linari
doaj   +2 more sources