Results 41 to 50 of about 6,059 (169)

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1934-1941, August 2026.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4+ lymphocytes

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2949-2959, August 2026.
Background Female sex hormones used in feminizing hormone therapy (FHT) may influence activation and persistence of HIV pre‐exposure prophylaxis (PrEP) medications. The clinical relevance of this interaction remains unclear, particularly for transgender and cisgender women (TGW and CGW).
Elizabeth Hastie, Megha Srivasta, Edward R. Cachay, Leah Burke, Sara Gianella, Stephen Rawlings, Frank Z. Stanczyk, Craig Sykes, Angela D. M. Kashuba, Jill Blumenthal, Mackenzie L. Cottrell   +10 more
wiley   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Volume 78, Issue 7, Page 1490-1499, July 2026.
Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and posttranscriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron splicing ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Glomerulopatías Primarias y Secundarias, Patología Renal

REV SEN
La sobrevida renal en glomerulopatías, tanto primarias como secundarias, depende del tipo específico de enfermedad, la gravedad de la lesión glomerular, la respuesta al tratamiento y la presencia de enfermedades coexistentes.
SLANH
doaj   +3 more sources

Histopathological findings in renal biopsies in Anderson–Fabry disease. Case series

Revista Médica del Hospital General de México, 2018
Anderson–Fabry disease is the second most common lysosomal storage disease after Gaucher disease. It is an X-linked lysosomal disorder that causes a deficiency in alpha-galactosidase, leading to the accumulation of globotriaosylceramide (Gb3) in the ...
A.L. Mena Rodríguez, M.V. Soto Abraham, M.Y. Valdespino Vázquez, B. de León Garza   +3 more
doaj   +1 more source

Significado de la enfermedad y el trasplante de vivo para las personas receptoras de riñón

Enfermería Nefrológica
Introducción: En el trasplante renal de donante vivo, la percepción de la situación de enfermedad y la vivencia personal influyen de forma significativa en la adaptación emocional y el afrontamiento de la persona.
Laura Rota Musoll, Meritxell Mondéjar Pont, Sònia Elvira Carrascal, Esmeralda Molina Robles, Ester Oriol Vila, Judit Bou Folgarolas   +5 more
doaj   +1 more source

Enfermedad renal crónica en adultos mayores institucionalizados en un centro de atención geriátrica

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2022
Fundamento: con el envejecimiento se va deteriorando el sistema renal, que unido a la coexistencia de enfermedades crónicas, como la hipertensión arterial y la diabetes mellitus, hacen que la población geriátrica esté propensa a padecer de enfermedad ...
Luis Mengana-Castillo, Miladis Portillo-Cabrera, Celeste Maribel Castañeda-Guerra, Inedelmis Gutiérrez-Batista   +3 more
doaj  

Prospective comparison of diagnostic accuracy of ultrasound, PET/CT and DW‐MRI for preoperative assessment of pelvic lymph nodes in cervical cancer patients: results of the CANNES trial

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 6, Page 836-851, June 2026.
ABSTRACT Objective To determine whether ultrasound is non‐inferior to positron‐emission tomography/computed tomography (PET/CT) and diffusion‐weighted magnetic resonance imaging (DW‐MRI) in terms of overall diagnostic accuracy for the preoperative assessment of pelvic lymph‐node status in cervical cancer.
F. Frühauf, D. Fischerová, F. Moro, R. Kocián, V. Ptáčník, M. Wagnerová, L. Lambert, A. C. Testa, N. Bizzarri, R. O. Perez, E. Teodorico, D. Cibula, Collaborators, V. Poonyakanok, C. Culcasi   +14 more
wiley   +1 more source

Urgencia hipertensiva secundaria a enfermedad poliquística renal autosómica recesiva en lactante. Reporte de caso

Acta Pediátrica de México, 2017
La enfermedad poliquística renal asociada a la fibrosis hepática congénita es una enfermedad hereditaria; se encuentra dentro del espectro de las enfermedades fibroquísticas hepatorrenales.
Roxana Quisbert-Cruz, Flora Zárate-Mondragón   +1 more
doaj   +1 more source