Results 31 to 40 of about 3,562 (203)

Enfermedades reumáticas y alergias, la dualidad del sistema inmunológico

Revista Alergia México, 2021
Las enfermedades reumáticas autoinmunes son trastornos multisistémicos que afectan principalmente las articulaciones y los músculos; algunos ejemplos de estas afecciones son la artritis reumatoide, el lupus eritematoso sistémico y el síndrome de Sjögren.
Gabriela Athziri Sánchez-Zuno, Edith Oregón-Romero, Jorge Hernández-Bello, Guillermo González-Estevez, Rodrigo Vargas-Rosales, José Francisco Muñoz-Valle   +5 more
doaj   +1 more source

IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms

BMC Molecular and Cell Biology, 2020
Introduction The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target to IL6/sIL6R
Alvaro Valin, Manuel J. Del Rey, Cristina Municio, Alicia Usategui, Marina Romero, Jesús Fernández-Felipe, Juan D. Cañete, Francisco J. Blanco, Yolanda Ruano, Gabriel Criado, José L. Pablos   +10 more
doaj   +1 more source

Sarilumab in Polyarticular-Course Juvenile Idiopathic Arthritis: Dose-Finding and 1-Year Analysis of a Phase 2b, Open-Label, Multicenter Study. [PDF]

Arthritis Care Res (Hoboken)
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
De Benedetti F, Penadés IC, Nikishina I, Foeldvari I, Spindler AJ, Kozlova A, Rubio-Pérez N, Quartier P, Żuber Z, Barria R, Clemente D, Cornejo GV, Marzan K, Liu N, Xu C, DiMartino S, Giannelou A, Cao-Ghoul F, Akinlade B, Baret-Cormel L.   +19 more
europepmc   +2 more sources

TFAM-deficient mouse skin fibroblasts – an ex vivo model of mitochondrial dysfunction

Disease Models & Mechanisms, 2021
Mitochondrial dysfunction associates with several pathological processes and contributes to chronic inflammatory and ageing-related diseases. Mitochondrial transcription factor A (TFAM) plays a critical role in maintaining mtDNA integrity and function ...
Manuel J. Del Rey, Carolina Meroño, Cristina Municio, Alicia Usategui, María Mittelbrunn, Inés García-Consuegra, Gabriel Criado, José L. Pablos   +7 more
doaj   +1 more source

La importancia del laboratorio en el diagnóstico del síndrome de Sjögren primario

Revista de la Facultad de Ciencias Médicas de Córdoba, 2009
El síndrome de Sjögren (SS) es una enfermedad autoinmune sistémica que se caracteriza fundamentalmente por la presencia de xeroftalmía y xerostomía debido a la infiltración de las glándulas lagrimales y salivares por células linfoplasmocitarias. Al igual
Pilar Brito-Zerón, Albert Bove, Marta Perez-de-Lis, Candido Diaz-Lagares, Myriam Gandía, Miriam Akasbi, María José Soto-Cardenas   +6 more
doaj   +1 more source

Global excellence in rheumatology in Latin America: The case of systemic lupus erythematosus

Frontiers in Medicine, 2023
Systemic lupus erythematosus (SLE) affects more severely non-White populations, due to their genetic background and sociodemographic characteristics.
Manuel F. Ugarte-Gil, Manuel F. Ugarte-Gil, Yurilis Fuentes-Silva, Victor R. Pimentel-Quiroz, Victor R. Pimentel-Quiroz, Guillermo J. Pons-Estel, Rosana Quintana, Bernardo A. Pons-Estel, Graciela S. Alarcón, Graciela S. Alarcón   +9 more
doaj   +1 more source

Uncovering Genetic Variation in Systemic Lupus Erythematosus Risk Variants in Indigenous Peruvians. [PDF]

ACR Open Rheumatol
Objective Systemic lupus erythematosus (SLE) results in worse clinical outcomes among individuals of Amerindian descent. The genetic basis for this is uncertain, and there is a significant lack of genetic research focused on Amerindian ancestry populations.
Lanata CM, Oppong RF, Horton MK, Borda V, Ugarte-Gil MF, Nititham J, Tarazona-Santos E, O'Connor TD, Guio H, Criswell LA.   +9 more
europepmc   +2 more sources

Pellagra ohne Niacinmangel?

, 2022
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 20, Issue 9, Page 1228-1230, September 2022.
Ines Bertlich, Maya Bertlich, Alexander Enk, Jochen Hoffmann, Ferdinand Toberer, Christine Fink   +5 more
wiley   +1 more source

Necrotizing Sarcoid Granulomatosis: A Disease Not to be Forgotten

Case Reports in Medicine, Volume 2020, Issue 1, 2020., 2020
Sarcoidosis is a systemic granulomatous disease of unknown aetiology characterised by the appearance of noncaseifying epithelioid granulomas in the affected organs, most commonly the lungs, skin, and eyes (Iannuzzi et al. 2007). Necrotizing Sarcoid Granulomatosis (NGS) is a rare and little‐known form of disease, which also presents nodular lung lesions,
A. I. Parejo-Morón, M. L. Tornero-Divieso, M. R. Férnandez-Díaz, L. Muñoz-Medina, O. Preda, N. Ortego-Centeno, Rolando Cimaz   +6 more
wiley   +1 more source

Casos estandarizados en reumatología. Enfermedades autoinmunes sistémicas [PDF]

, 2021
Introducción. Las enfermedades autoinmunes sistémicas, denominadas también colagenosis o conectivopatías, constituyen una heterogéneo grupo de procesos que presentan en común: los fenómenos de autoinmunidad, que tienen valor patogénico y, en muchas ...
Nolla Solé, Joan Miquel
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