Results 41 to 50 of about 7,578 (209)

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO

Nature Communications, 2021
Aortic aneurysm and dissection, the major problem linked to Marfan syndrome (MFS), lacks effective pharmacological treatment. Here, the authors show that the NO pathway is overactivated in MFS and that inhibition of guanylate cyclase and cGMP-dependent ...
Andrea de la Fuente-Alonso, Marta Toral, Alvaro Alfayate, María Jesús Ruiz-Rodríguez, Elena Bonzón-Kulichenko, Gisela Teixido-Tura, Sara Martínez-Martínez, María José Méndez-Olivares, Dolores López-Maderuelo, Ileana González-Valdés, Eusebio Garcia-Izquierdo, Susana Mingo, Carlos E. Martín, Laura Muiño-Mosquera, Julie De Backer, J. Francisco Nistal, Alberto Forteza, Arturo Evangelista, Jesús Vázquez, Miguel R. Campanero, Juan Miguel Redondo   +20 more
doaj   +1 more source

Differential contribution of T‐type voltage‐gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits

Experimental Physiology, EarlyView.
Abstract figure T‐type VGCCs contribute to the contraction of the rabbit aorta and modulate both contraction and vasodilation in the rabbit renal artery. α1, alpha 1 adrenergic receptor; ATR, angiotensin II receptor; Ang II, angiotensin II; CaM, calmodulin; Cav3, T‐type voltage‐gated Ca2⁺ channels; cGMP, cyclic guanidine monophosphate; EC, endothelial ...
Andrea Suarez, Sol Guerra‐Ojeda, Manuel Zarzoso, Marta Serna‐García, Jose M. Vila, Eva Serna, Maria D. Mauricio   +6 more
wiley   +1 more source

FACTORES DE RIESGO CARDIOVASCULAR

Ciencia & Salud, 2020
Las enfermedades cardiovasculares son la principal causa de muerte a nivel mundial, cada año mueren más personas por enfermedades cardiovasculares que por cualquier otra causa de muerte. En Costa Rica, las enfermedades cardiovasculares constituyen una de
Daniel Chevez Elizondo
doaj   +1 more source

Disruption of ATP Synthase Spatiotemporal Organization, Ca2+ Dynamics, and Contractile Function in Senescent Cardiomyocytes

Aging Cell, Volume 25, Issue 2, February 2026.
Enhanced ATP hydrolysis, ΔΨm flickering, and destabilized ATP synthase dimers collectively reduce ATP availability in senescent cardiomyocytes. This energy deficit is associated with disrupted Ca2⁺ dynamics and contractility. ABSTRACT Heart disease is the leading cause of death in the elderly population.
Silke Morris, Nico Marx, Gonzalo Barrientos, Isidora Molina‐Riquelme, Frank Schmelter, Hugo E. Verdejo, Stefan Peischard, Guiscard Seebohm, Verónica Eisner, Karin B. Busch   +9 more
wiley   +1 more source

Workflow for the Isolation and Characterisation of Human Milk Extracellular Vesicles (HMEVs) and Their Inflammatory Biomarker Profile

Journal of Extracellular Biology, Volume 5, Issue 1, January 2026.
ABSTRACT Human milk extracellular vesicles (HMEVs), secreted by mammary epithelial cells, are enriched in bioactive molecules that support intestinal epithelial integrity. Among these, oxylipins, that is, lipid mediators derived from polyunsaturated fatty acids, are gaining interest for their immunomodulatory and neuroprotective functions in breastfed ...
Jose Luis Moreno‐Casillas, Laura Ripoll‐Seguer, Isabel Ten‐Doménech, Marta Gómez‐Ferrer, Pilar Sepúlveda, Abel Albiach‐Delgado, Juan Daniel Sanjuan‐Herráez, María Gormaz, David Pérez‐Guaita, Bernhard Lendl, María Cernada, Guillermo Quintás, Julia Kuligowski   +12 more
wiley   +1 more source

Revisiting tricuspid regurgitation: Historical insights and emerging research perspectives

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Tricuspid regurgitation (TR), once seen as benign, is now recognized as a serious and increasingly prevalent condition linked to aging and better imaging. Its association with greater morbidity and mortality has shifted clinical perspectives towards early diagnosis and intervention.
Claudia Gonzalez‐Cucharero, Gemma Vilahur, Marta Saura, Rocío Hinojar, Jose L. Zamorano, Carlos Zaragoza   +5 more
wiley   +1 more source

Mujer y enfermedades cardiovasculares

, 2023
Las enfermedades cardiovasculares (ECV) son desde hace muchos años una de las principales causas de mortalidad en el mundo, de ahí que hayan sido el foco de numerosos estudios en la medicina. Sin embargo, ni el diagnóstico ni el tratamiento han tenido siempre la misma importancia en hombres que en mujeres.
Durán-Ávila, José Javier, Amador Castilla, Laura Mariana, Reyes-Molina, Araceli, Díaz del Pino, Enrique   +3 more
openaire   +1 more source

Integrated biomarker landscape for the early detection and management of calcific aortic valve disease

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Calcific aortic valve disease (CAVD), the leading valvular disorder in older adults, progresses from sclerosis to severe stenosis without effective medical therapies, making early non‐invasive detection essential. Circulating and mechanistic biomarkers reflect core pathogenic axes, including lipid oxidation, inflammation, mineral metabolism ...
Alberto Cook‐Calvete, Silvia Moreta, Maria Delgado‐Marin, Blanca Fernandez‐Rodriguez, Carlos Zaragoza, Marta Saura   +5 more
wiley   +1 more source

Revisión bibliográfica sobre el ejercicio físico y la cesación del hábito de fumar en adolescentes y adultos jovenes sanos

Revista Colombiana de Medicina Física y Rehabilitación, 2012
El presente estudio tiene como objetivo realizar una revisión bibliográfica de investigaciones publicadas en las principales bases de datos médicas mundiales, que estudien el efecto del ejercicio en el abandono del hábito de fumar en adolescentes y ...
Ana María Acosta Tobón, Ángela María Giraldo Ramírez, Amaury Montes de Oca Allín   +2 more
doaj  

De la paliación neonatal al Fontan: el peaje de la cirugía del corazón univentricular. Análisis de resultados de las diferentes técnicas quirúrgicas

Cirugía Cardiovascular, 2016
Introducción y objetivos: Evaluación de resultados en cirugía univentricular. Pacientes y métodos: Análisis retrospectivo de 42 pacientes intervenidos entre 2013-2015.
Esteban Sarria García, Enrique Ruiz Alonso, Rafael Castillo Martín, Beatriz Picazo Angelín, Victorio Cuenca Peiró, Lourdes Conejo Muñoz, Juan I. Zabala Argüelles   +6 more
doaj   +1 more source