Results 111 to 120 of about 1,719 (241)
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, Volume 36, Issue 4, July 2026.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
Tenedores de fauna silvestre en cautiverio en el Municipio de El Paujil - Caquetá
Revista de la Facultad de Ciencias Agropecuarias, 2015 El Municipio de Paujil- Caquetá esta ubicado en el piedemonte amazónico, por lo que cuenta con una abundante biodiversidad; sin embargo, por sus características sociales y culturales, se hace fiecuente la tenencia en cautiverio de fauna silvestre ...
G. E. Estrada +3 more
doaj
Brain Pathology, Volume 36, Issue 4, July 2026.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source
Revista Colombiana de Biotecnología, 1999 Cuando se realiza investigación en un marco pleno de ética y se mantiene el bienestar de los animales, la calidad de la ciencia y los datos que se deriven del trabajo serán lo mejor que se puede lograr.
A. Mrad, C. A. Cardozo
doaj
Drug and Alcohol Review, Volume 45, Issue 5, July 2026.ABSTRACT Introduction Uptake of evidence‐based medication for opioid use disorder (MOUD), including buprenorphine–naloxone, remains low despite the expanding US opioid crisis. This study examined participants' and staff perceptions of adopting and delivering buprenorphine–naloxone on a mobile unit providing integrated MOUD and HIV services for people ...
Rose A. Schmidt +17 more
wiley +1 more source
Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.ABSTRACT Background Influenza causes 650,000 deaths, 3–5 million hospitalizations, and 1 billion cases worldwide each year. There is a limited repertoire of antivirals available to tackle this burden, highlighting the risk of developing resistance to current drugs.
Alejandro Martín‐Toribio +15 more
wiley +1 more source
Modelos experimentales de enfermedad cardiovascular Experimental models of cardiovascular disease
Nutrición Hospitalaria, 2007 El presente trabajo describe los modelos experimentales de utilidad clínica en el estudio de las enfermedades cardiovasculares y hace énfasis en los modelos usados para determinar los mecanismos fisiopatológicos de la aterosclerosis, así como para ...
A. Gil Hernández +3 more
doaj
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)‐Enriched Extracellular Vesicles that Promote Angiogenesis. The results from this study suggest that EVs isolated from blood immediately after the last bout of endurance exercise training (ExerV) are enriched in antioxidants. ExerVs stimulate vascular growth both in vitro and in
Alexander M. Fliflet +23 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Microgravity (μG) reduces mechanical tactile stimulation in Caenorhabditis elegans, causing neuromuscular decline, altered gene expression, synaptic defects, and accelerated aging phenotypes. The gentle‐touch mechanoreceptor MEC‐4 mediates μG‐induced body length reduction and extracellular matrix gene downregulation.
Atsushi Higashitani +16 more
wiley +1 more source