Results 71 to 80 of about 294,544 (230)

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Uso terapéutico de las vesículas extracelulares en insuficiencia renal aguda y crónica

Nefrología, 2017
En la década de los 90 se descubrió un nuevo sistema de comunicación célula-célula, que consiste en la liberación de vesículas cargadas con partículas bioactivas (proteínas, mRNA, miRNA, metabolitos, etc.) en el espacio extracelular.
Jordi Rovira, Fritz Diekmann, Josep M. Campistol, María José Ramírez-Bajo   +3 more
doaj   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, Volume 78, Issue 11, Page 1618-1630, November 2026.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, Volume 78, Issue 11, Page 1781-1790, November 2026.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

Enfermedades tubulares. Pielonefritis

, 2021
En el tercer capítulo para completar el estudio de las enfermedades que afectan a los distintos segmentos de la nefrona, se abordan los principales procesos que afectan a los túbulos renales.
Macías García, Beatriz, González Solís, Mario Alberto   +1 more
core  

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2280-2291, November 2026.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source

Enfermedad renal crónica y olfato

Nefrología, 2020
Resumen: Las alteraciones en el sentido del olfato (disosmia, anosmia, hiposmia) son frecuentes en los pacientes con enfermedad renal crónica; sin embargo, hasta el momento actual las causas, consecuencias y tratamiento de estas alteraciones han sido poco abordadas.
M. Ludivina Robles-Osorio, Rebeca Corona, Teresa Morales, Ernesto Sabath   +3 more
openaire   +2 more sources

Surviving Males With PORCN Variants: Expanding the Clinical, Molecular, and Mechanistic Spectrum

Clinical Genetics, Volume 110, Issue 5, Page 605-615, November 2026.
Pathogenic PORCN variants are compatible with male survival in both mosaic and non‐mosaic states, expanding the FDH/PONGOS spectrum and improving diagnosis and genetic counseling. ABSTRACT Pathogenic variants in PORCN cause focal dermal hypoplasia (FDH/Goltz syndrome), an X‐linked dominant disorder historically considered lethal in males, with milder ...
Lucía Miranda‐Alcaraz, Simone Carbonera, Mónica Mora‐Gómez, Natalia Gallego‐Zazo, Inmaculada Guillén, Elena Padilla, Gaia Visani, Alessia Asaro, Valeria Vásquez‐Amell, Mario Cazalla, Manuel Rodríguez‐Canó, Cristina Silván, Pedro Arias, Juan Andrés Jiménez‐Estrada, Tomás Valle, Alejandro Cruz‐Utrilla, Pilar Escribano‐Subías, Nuria Ochoa Parra, María Jesús del Cerro Marín, Julián Nevado, Spanish PAH Consortium, Pablo Lapunzina, Fabio Sirchia, Jair Tenorio‐Castano   +23 more
wiley   +1 more source

Vol. 28, nº 49. Evaluación de la respuesta de pacientes trasplantados renales a EvusheldTM (Cilgavimab/Tixagevimab)

, 2023
Enfermedades de Declaración Obligatoria por provincias. Semana 49/2023 y acumulado desde la semana 01/2023. Datos provisionales. Incluye además el artículo titulado “Evaluación de la respuesta de pacientes trasplantados renales a EvusheldTM (Cilgavimab ...
Servicio de Vigilancia y Salud Laboral
core  

A Semi‐Interpretable Multimodal Model Combining Electronic Health Records and Chest X‐Rays for COVID‐19‐Related Death Prediction

Expert Systems, Volume 43, Issue 11, November 2026.
ABSTRACT Purpose Prognostic models can benefit from integrating heterogeneous data sources. While deep learning‐based multimodal models often improve predictive performance, their limited interpretability remains a barrier to clinical adoption. Moreover, achieving robust generalization with such models typically requires large and diverse datasets ...
Lander Rodriguez‐Idiazabal, Jose M. Quintana, Javier Del Ser, Jose Javier Echevarria‐Uraga, Maria Jose Legarreta, Nere Larrea, Fernando García‐García, Irantzu Barrio   +7 more
wiley   +1 more source