Results 51 to 60 of about 935 (183)

The Genetic and Cellular Basis of Autosomal Dominant Polycystic Kidney Disease—A Primer for Clinicians

open access: yesFrontiers in Pediatrics, 2017
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders worldwide. In recent decades, the field has undergone a revolution, starting with the identification of causal ADPKD genes, including PKD1, PKD2, and the ...
Adrián Cordido   +2 more
doaj   +1 more source

Clinical evolution of chronic renal patients with HIV infection in replacement therapy

open access: yesNefrología (English Edition), 2015
Patients on renal replacement therapy (RRT) infected with the human immunodeficiency virus (HIV) are a special group with growing interest. In order to study the epidemiological data of HIV+ patients on RRT in Spain, we collected individual information ...
Ramón Saracho   +27 more
doaj   +1 more source

Skin Abnormalities at Checkpoint Inhibitor Therapy Initiation Are Associated With Skin Rash Development in Oncology Patients

open access: yesAllergy, EarlyView.
Skin tape strip lipidomic analysis revealed preexisting skin barrier lipid abnormalities at day 0 that were further exacerbated after 6 weeks of CPI treatment. Significant changes in skin (but not plasma) proinflammatory cytokines were identified in future ircAE patients after 6 weeks of CPI immunotherapy.
Taras Lyubchenko   +9 more
wiley   +1 more source

Clinical Burden of Symptomatic HEV‐3 Infection in Southern Spain

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
Clinical burden of symptomatic HEV‐3 infection in southern Spain. Between 2022 and 2025, 1124 patients with acute hepatitis, defined as ALT ≥ 3 times the upper limit of normal and negative screening for HAV, HBV, HCV, EBV and CMV, were evaluated in Andalusia.
María Casares‐Jimenez   +14 more
wiley   +1 more source

Survival outcomes and treatment patterns in myelofibrosis in the JAK inhibitor era

open access: yesBritish Journal of Haematology, EarlyView.
Summary Data on real‐world survival and treatment patterns in large, unselected myelofibrosis (MF) cohorts remain limited. We analysed 1649 patients with MF diagnosed from 2010 onwards and included in the Spanish Myelofibrosis Registry across 64 centres. Janus kinase (JAK) inhibitors were administered to approximately half of the patients.
Juan‐Carlos Hernández‐Boluda   +35 more
wiley   +1 more source

Treatment of hyperuricemias

open access: yesRevista de Nefrología, Diálisis y Trasplante, 2017
Asymptomatic hyperuricemia (AH) and other disorders associated with uric acid (UA) are treated differently according to the patient’s clinical state and to the stage of renal disease (RD).
Paula Iscoff   +3 more
doaj  

Uso terapéutico de las vesículas extracelulares en insuficiencia renal aguda y crónica

open access: yesNefrología, 2017
En la década de los 90 se descubrió un nuevo sistema de comunicación célula-célula, que consiste en la liberación de vesículas cargadas con partículas bioactivas (proteínas, mRNA, miRNA, metabolitos, etc.) en el espacio extracelular.
Jordi Rovira   +3 more
doaj   +1 more source

Leisure‐Time Physical Activity on Age‐Modelled Trajectories of Body Mass Index and Obesity Risk Throughout Life: Multivariable Regression and Mendelian Randomization Analyses Using Electronic Health Record Data From the CORDELIA‐Catalunya Study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess whether self‐reported leisure‐time physical activity, moderate‐to‐vigorous leisure‐time physical activity, and genetically determined cardiorespiratory fitness are associated with age‐related BMI trajectories and incident obesity. Methods We pooled 14 993 adults (30–90 years; 52.7% women; cohorts: REGICOR‐ACRISC, ILERVAS, ARTPER)
Javier Hernando‐Redondo   +13 more
wiley   +1 more source

Glomerulonefritis por biopsia en población atendida en el Hospital Nacional Dos de Mayo. Lima, 2007-2016

open access: yesAnales de la Facultad de Medicina, 2018
Introducción. La biopsia renal percutánea es uno de los procedimientos que más ha contribuido al conocimiento de las enfermedades renales. Nuestro país no cuenta con datos actualizados sobre este tema en específico.
Guillermo Valdez-Yánez   +6 more
doaj   +1 more source

Real‐World Effectiveness and Safety of Finerenone in People With Type 2 Diabetes and Chronic Kidney Disease: A Spanish Multicentre Retrospective Observational Study (MEDFINE‐RWD)

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Although finerenone has shown efficacy in randomized trials, evidence from routine clinical practice remains limited. We aimed to assess the real‐world effectiveness and safety of finerenone in people with type 2 diabetes (PWT2D) and chronic kidney disease (CKD), with a particular focus on residual cardiorenal risk as reflected by changes ...
Oscar Moreno‐Pérez   +13 more
wiley   +1 more source

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