Results 61 to 70 of about 939 (186)

Leisure‐Time Physical Activity on Age‐Modelled Trajectories of Body Mass Index and Obesity Risk Throughout Life: Multivariable Regression and Mendelian Randomization Analyses Using Electronic Health Record Data From the CORDELIA‐Catalunya Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess whether self‐reported leisure‐time physical activity, moderate‐to‐vigorous leisure‐time physical activity, and genetically determined cardiorespiratory fitness are associated with age‐related BMI trajectories and incident obesity. Methods We pooled 14 993 adults (30–90 years; 52.7% women; cohorts: REGICOR‐ACRISC, ILERVAS, ARTPER)
Javier Hernando‐Redondo, Anna Camps‐Vilaró, Roberto Elosua, Eleonora Fornara, Marcelino Bermúdez‐López, Pere Torán‐Monserrat, Ainara Jiménez‐Navarro, José M. Valdivielso, Víctor M. López‐Lifante, Tomàs Salas‐Fernández, Serafí Cambray, Raquel Cruz, Jaume Marrugat, Álvaro Hernáez   +13 more
wiley   +1 more source

Real‐World Effectiveness and Safety of Finerenone in People With Type 2 Diabetes and Chronic Kidney Disease: A Spanish Multicentre Retrospective Observational Study (MEDFINE‐RWD)

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Although finerenone has shown efficacy in randomized trials, evidence from routine clinical practice remains limited. We aimed to assess the real‐world effectiveness and safety of finerenone in people with type 2 diabetes (PWT2D) and chronic kidney disease (CKD), with a particular focus on residual cardiorenal risk as reflected by changes ...
Oscar Moreno‐Pérez, Antonio Tejera‐Muñoz, Patricia Tomás‐Gómez, Federico Vázquez‐San Miguel, Virginia Soria‐Utrilla, Ada María Roldán‐Sánchez, Maya Sánchez‐Baya, Jersy Cárdenas‐Salas, Blanca Timón‐Vázquez, Juan J. Gorgojo‐Martínez, Ines Modrego‐Pardo, Irea Fernández‐Xove, Jose Carlos Fernández‐García, Rebeca Reyes‐García   +13 more
wiley   +1 more source

Eco‐Epidemiological Study of Seropositivity Against Rickettsia and Leptospira Agents in Rural Areas of Urabá, Colombia

Tropical Medicine &International Health, EarlyView.
ABSTRACT Introduction Rickettsioses and leptospirosis are infectious diseases often underdiagnosed due to limited knowledge about their epidemiology, pathophysiology, and clinical aspects. Objectives To characterize the seroprevalence and seroincidence of Rickettsia and Leptospira agents and determine their associated factors in rural areas of Urabá ...
Mariana Torres‐Bustamante, Omar Cantillo‐Barraza, Albert I. Ko, Elsio A. Wunder Jr, Juan C. Quintero‐Vélez   +4 more
wiley   +1 more source

Ecological and Individual‐Level Factors Associated With Hantavirus Cardiopulmonary Syndrome Notifications and in‐Hospital Mortality Among Hospitalized Patients in Chile, 2005–2022

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Hantavirus cardiopulmonary syndrome (HCPS) is a severe zoonotic disease caused by Orthohantavirus andesense (Andes virus, ANDV), with significant public health burden in Chile. Despite decades of surveillance, knowledge gaps remain regarding the ecological drivers of notification burden and the individual‐level determinants of in ...
Benjamín Diethelm‐Varela, Nicolhole Atero, Fernanda Sánchez‐Rodríguez, Constanza Martínez‐Valdebenito, Carolina Henríquez, Francisca Córdova‐Bührle, Marcela Ferrés, Fernando O. Mardones   +7 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1934-1941, August 2026.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4+ lymphocytes

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2949-2959, August 2026.
Background Female sex hormones used in feminizing hormone therapy (FHT) may influence activation and persistence of HIV pre‐exposure prophylaxis (PrEP) medications. The clinical relevance of this interaction remains unclear, particularly for transgender and cisgender women (TGW and CGW).
Elizabeth Hastie, Megha Srivasta, Edward R. Cachay, Leah Burke, Sara Gianella, Stephen Rawlings, Frank Z. Stanczyk, Craig Sykes, Angela D. M. Kashuba, Jill Blumenthal, Mackenzie L. Cottrell   +10 more
wiley   +1 more source

Colangiopatía uremígena (síndrome de Varela Fuentes)

Cirugía del Uruguay, 2020
En carácter de segunda parte de trabajo anterior, se estudian 18 observaciones de "colangiopatía uremígena" (Demeulanaere) caracterizados esencialmente por la asociación de angiocolitis obstructiva y falla renal, en el curso de cuadros biliares agudos.
Ruben Gary, Federico Latourrette, Walter Acosta Ferreira   +2 more
doaj  

Ecografía en enfermedad renal

RECIAMUC
El sistema renal comprende una amplia variedad de funciones en el organismo de los seres vivos, entre las que se destacan el equilibrio ácido base, equilibrio hidroelectrolítico, filtración de productos metabólicos y toxinas de la sangre, producción de hormonas como la eritropoyetina, control de líquido extracelular, entre otras funciones.
Karen Mishell Santamaria Salazar, Jhonatan Enrique Redroban Lara, Milton Geovanny Luna Solano, Abraham Rafael Abril Núñez   +3 more
openaire   +1 more source

Hypertension at 5 months postpartum in women with gestational diabetes

Ultrasound in Obstetrics &Gynecology, Volume 68, Issue 2, Page 202-210, August 2026.
ABSTRACT Objective Gestational diabetes mellitus (GDM) is associated with future maternal cardiovascular disease, independent of the development of Type‐2 diabetes mellitus. As a major cardiovascular risk factor, we examined the incidence and predictors of hypertension at 5 months postpartum in women with previous GDM.
C. Gómez Fernández, M. Charakida, M. Moser, R. Breiviene, T. Mansukhani, L. A. Magee, P. von Dadelszen, K. H. Nicolaides   +7 more
wiley   +1 more source