Results 61 to 70 of about 935 (183)

Eco‐Epidemiological Study of Seropositivity Against Rickettsia and Leptospira Agents in Rural Areas of Urabá, Colombia

Tropical Medicine &International Health, EarlyView.
ABSTRACT Introduction Rickettsioses and leptospirosis are infectious diseases often underdiagnosed due to limited knowledge about their epidemiology, pathophysiology, and clinical aspects. Objectives To characterize the seroprevalence and seroincidence of Rickettsia and Leptospira agents and determine their associated factors in rural areas of Urabá ...
Mariana Torres‐Bustamante, Omar Cantillo‐Barraza, Albert I. Ko, Elsio A. Wunder Jr, Juan C. Quintero‐Vélez   +4 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1934-1941, August 2026.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4+ lymphocytes

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2949-2959, August 2026.
Background Female sex hormones used in feminizing hormone therapy (FHT) may influence activation and persistence of HIV pre‐exposure prophylaxis (PrEP) medications. The clinical relevance of this interaction remains unclear, particularly for transgender and cisgender women (TGW and CGW).
Elizabeth Hastie, Megha Srivasta, Edward R. Cachay, Leah Burke, Sara Gianella, Stephen Rawlings, Frank Z. Stanczyk, Craig Sykes, Angela D. M. Kashuba, Jill Blumenthal, Mackenzie L. Cottrell   +10 more
wiley   +1 more source

High‐Dimensional Immune Profiling Identifies Circulating NKT‐Like Cells Associated With Severity Outcome in Acute Pancreatitis at Disease Onset

Immunology, Volume 178, Issue 4, Page 685-703, August 2026.
High‐dimensional spectral cytometry of peripheral blood mononuclear cells at hospital admission revealed that acute pancreatitis patients who subsequently developed moderately‐to‐severe disease exhibited a specific reduction of circulating CD2 + CD8dim NKT‐like cells, which appear to acquire an altered cytotoxic‐like phenotype upon IL‐15 stimulation ...
Carolina González de Castro, Mª. Lourdes Ruiz Rebollo, Paloma Cal‐Sabater, Elisa Arribas‐Rodríguez, Álvaro Martín‐Muñoz, Alejandro Gonzalez del Hierro, Marina Perez Mazzali, Jessica Matesanz‐Isabel, Hugo Gonzalo‐Benito, Sara Cuesta‐Sancho, David Bernardo   +10 more
wiley   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Colangiopatía uremígena (síndrome de Varela Fuentes)

Cirugía del Uruguay, 2020
En carácter de segunda parte de trabajo anterior, se estudian 18 observaciones de "colangiopatía uremígena" (Demeulanaere) caracterizados esencialmente por la asociación de angiocolitis obstructiva y falla renal, en el curso de cuadros biliares agudos.
Ruben Gary, Federico Latourrette, Walter Acosta Ferreira   +2 more
doaj  

Ecografía en enfermedad renal

RECIAMUC
El sistema renal comprende una amplia variedad de funciones en el organismo de los seres vivos, entre las que se destacan el equilibrio ácido base, equilibrio hidroelectrolítico, filtración de productos metabólicos y toxinas de la sangre, producción de hormonas como la eritropoyetina, control de líquido extracelular, entre otras funciones.
Karen Mishell Santamaria Salazar, Jhonatan Enrique Redroban Lara, Milton Geovanny Luna Solano, Abraham Rafael Abril Núñez   +3 more
openaire   +1 more source

Enfermedad de Castleman unicéntrica renal [PDF]

Revista Mexicana de Urología, 2017
ANTECEDENTES: la enfermedad de Castleman describe un grupo de alteraciones linfoproliferativas causada por la producción excesiva de citocinas proinflamatorias, principalmente por interleucina-6 (IL-6). Los pacientes manifiestan signos y síntomas clínicos heterogéneos, con hallazgos histopatológicos de nódulos linfáticos y disfunción orgánica múltiple ...
openaire   +1 more source

Autoanticuerpos frente a proteínas de la vía alternativa del complemento en enfermedad renal

Nefrología, 2016
La activación del sistema del complemento interviene en el desarrollo de varias enfermedades renales, como las glomerulonefritis mediadas por anticuerpos, el daño por isquemia-reperfusión en los trasplantes renales o el rechazo de los injertos.
Pilar Nozal, Margarita López-Trascasa
doaj   +1 more source