Results 181 to 190 of about 178,841 (287)

Cross‐Coupling Reactions in Aqueous Micellar Media

open access: yesEuropean Journal of Organic Chemistry, Accepted Article.
Thanks to their ability to efficiently and reliably construct carbon‐carbon and carbon‐heteroatom bonds, cross‐coupling reactions remain at the forefront of chemical research in both academic and industrial settings. However, the growing emphasis on sustainability has exposed the shortcomings of cross‐coupling chemistry in several areas, including the ...
Alexander Uner, Liam Thomas Ball
wiley   +1 more source

Synthesis of Bioorthogonal Mycolic Acids: Chemoselective Reduction of β‐Ketoesters Containing an Alkyne Using the Noyori Catalyst

open access: yesEuropean Journal of Organic Chemistry, Accepted Article.
The asymmetric reduction of β‐ketoesters using the Noyori catalyst is a highly effective synthetic methodology, offering excellent stereocontrol for the preparation of enantiopure b‐hydroxyesters from prochiral substrates in high yields. This reaction has been used in the total synthesis of mycolic acids, which are α‐alkyl, β‐hydroxy fatty acids ...
Paulin Rollando   +5 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

Bradycardia is induced by hyperactivity of the vagus nerve and nucleus ambiguus during seizures propagating into the brainstem

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Seizure‐induced bradycardia and asystole have been documented by video‐EEG monitoring periods in patients with epilepsy. This cardiac dysfunction during or after seizures may contribute to sudden unexpected death in epilepsy (SUDEP). Abnormal neurocardiac function during seizures could potentially be caused by seizures propagating to
Chia‐Chu Chiang   +2 more
wiley   +1 more source

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