Results 131 to 140 of about 2,795,262 (398)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Automotive Stirling Engine Development Program [PDF]
Mod I engine testing and test results, the test of a Mod I engine in the United States, Mod I engine characterization and analysis, Mod I Transient Test Bed fuel economy, Mod I-A engine performance are discussed.
Antonelli, M. +5 more
core +1 more source
, 1982 A solar engine is disclosed in which a fluid, which is first heated and then cooled, forces a piston outward as the fluid is heated, and then draws the piston inward as the fluid is cooled. The piston is connected to a shaft and produces work as it moves
Jensen, R. N.
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Gas turbine engine with recirculating bleed [PDF]
, 1978 Carbon monoxide and unburned hydrocarbon emissions in a gas turbine engine are reduced by bleeding hot air from the engine cycle and introducing it back into the engine upstream of the bleed location and upstream of the combustor inlet. As this hot inlet
Adamson, A. P.
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
AN ADAPTIVE MODEL-BASED FRAMEWORK FOR PROGNOSTICS OF GAS PATH FAULTS IN AIRCRAFT GAS TURBINE ENGINES
International Journal of Prognostics and Health Management, 2019 This paper presents an adaptive framework for prognostics in civil aero gas turbine engines, which incorporates both performance and degradation models, to predict the remaining useful life of the engine components that fail predominantly by gradual ...
Ogechukwu Alozie +4 more
doaj +1 more source
Development and Evaluation of the Predictive Capabilities of a Dual-Fuel Combustion Model with Methanol or Hydrogen in a Medium Speed Large Bore Engine [PDF]
, 2023 Jeroen Dierickx +4 more
openalex +1 more source