Results 31 to 40 of about 478,005 (227)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Semantic model-driven development of web service architectures. [PDF]

, 2008
Building service-based architectures has become a major area of interest since the advent of Web services. Modelling these architectures is a central activity. Model-driven development is a recent approach to developing software systems based on the idea
Pahl, Claus
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Defining Robust NVH Requirements for an Electrified Powertrain Mounting System Based on Solution Space During Early Phase of Development

Applied Sciences
Electrification introduces additional NVH (noise, vibration and harshness) challenges during the development of powertrain mounting systems due to high-frequency excitations from the powertrain and the absence of masking effects from the combustion ...
José G. Cóndor López, Karsten Finger, Sven Herold   +2 more
doaj   +1 more source

Near-IR 2D-Spectroscopy of the 4''x 4'' region around the Active Galactic Nucleus of NGC1068 with ISAAC/VLT

, 2002
We present new near-IR long slit spectroscopic data obtained with ISAAC on VLT/ANTU (ESO/Paranal) of the central 4''x 4'' region surrounding the central engine of NGC1068 . Bracket Gamma (Bg) and H2 emission line maps and line profile grids are produced,
Alloin, Bland-Hawthorn, Blietz, Bock, Brinks, Capetti, Cecil, D. Alloin, Draine, E. Galliano, Efstathiou, Gallimore, Gallimore, Glass, Granato, Granato, Hall, Heckman, Helfer, Krolik, Machetto, Maloney, Marco, Marco, Moorwood, Mouri, Muxlow, Oliva, Pier, Quillen, Rotaciuc, Rouan, Rousselot, Schinnerer, Tacconi, Thatte, Thompson, Thompson, Tomono, Wittkowski   +39 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

GRIDCC: Real-time workflow system [PDF]

, 2007
The Grid is a concept which allows the sharing of resources between distributed communities, allowing each to progress towards potentially different goals.
Akram, A, Colling, D, Dickens, L, Guo, L, Kyberd, P, Martyniak, J, McGough, A, Powell, R S   +7 more
core  

A Framework for Designing 3d Virtual Environments [PDF]

, 2011
The process of design and development of virtual environments can be supported by tools and frameworks, to save time in technical aspects and focusing on the content.
Catanese, Salvatore, Ferrara, Emilio, Fiumara, Giacomo, Pagano, Francesco   +3 more
core   +3 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source