Results 41 to 50 of about 478,005 (227)

Enhancement of thrust reverser cascade performance using aerodynamic and structural integration [PDF]

, 2004
This paper focuses on the design of a cascade within a cold stream thrust reverser during the early, conceptual stage of the product development process.
Armstrong, Cecil, Butterfield, Joseph, Bénard, Emmanuel, Cooper, Richard K., Monaghan, D., Price, Mark, Raghunathan, Srinivasan, Yao, H.   +7 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Cryogenic propellant management: Integration of design, performance and operational requirements [PDF]

, 1985
The integration of the design features of the Shuttle elements into a cryogenic propellant management system is described. The implementation and verification of the design/operational changes resulting from design deficiencies and/or element ...
Cole, T. W., Jamieson, J. R., Jr., Lak, T. I., Worlund, A. L.   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

HIGH TEMPERATURE LOAD MEASUREMENT FOR NOZZLE COMPONENT OF A CERTAIN AERO-ENGINE

Jixie qiangdu, 2019
T4 link is the critical load-bearing component for nozzle element of a certain engine. Whether the nozzle load meets the requirements or not at high temperature is the key factor in the structural integrity of the nozzle unit.
XU YanZhi, LEI XiaoBo, WEN Min, HU ChunXiao, ZHAO Bo   +4 more
doaj  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Blade loss transient dynamics analysis, volume 2. Task 2: Theoretical and analytical development. Task 3: Experimental verification [PDF]

The component element method was used to develop a transient dynamic analysis computer program which is essentially based on modal synthesis combined with a central, finite difference, numerical integration scheme.
Bach, L. J., Gaffney, E. F., Gallardo, V. C., Stallone, M. J., Storace, A. S.   +4 more
core   +1 more source

Finite Element Simulation of a Steady-State Stress Distribution in a Four Stroke Compressed Natural Gas-Direct Injection Engine Cylinder Head [PDF]

, 2006
The main aim of this work is to predict the design performance based on the stress/strain and thermal stress behaviour of cylinder head under various operating conditions.
Abdullah, S., Ariffin, A. K., Shamsudeen, A.   +2 more
core  

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source