Results 61 to 70 of about 407,181 (305)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Selecting Cycle and Design Parameters of a Super Critical CO2 Cycle for a 180 kW Biogas Engine

Energies
The objective of this paper was to study the sCO2 cycle as a waste heat recovery system for a 180 kW biogas engine. The research methodology adopted was numerical simulations through two models built in different programs: Aspen HYSYS and GT Suite.
Jarosław Milewski, Arkadiusz Szczęśniak, Piotr Lis, Łukasz Szabłowski, Olaf Dybiński, Kamil Futyma, Arkadiusz Sieńko, Artur Olszewski, Tomasz Sęk, Władysław Kryłłowicz   +9 more
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

METHODOLOGY FOR ESTIMATION OF HEAT-STRESSED STATE FOR CYLINDER HEAD OF DIESEL ENGINE WITH AIR COOLING

Наука и техника, 2016
Performance tuning improvement of modern diesel engines exerts an influence on technical and economic, ecological and resource indices of an internal combustion engine (ICE).
A. N. Avramenko
doaj   +1 more source

Measurement Parameter Selection on Adaptive Cycle Engine Gas Path Fault Diagnosis

Energy Procedia, 2019
Abstract Adaptive cycle engine has extraordinary performance in overall range. There is little public research on gas path fault diagnosis of adaptive cycle engine. The increased rotating components and variable mechanisms increase the diagnosis difficulty of adaptive cycle engine. Therefore, analysis mainly focused on how to simplify the fault modes
Yihao Xu, Hailong Tang, Min Chen
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Engine Load Effects on the Energy and Exergy Performance of a Medium Cycle/Organic Rankine Cycle for Exhaust Waste Heat Recovery

Entropy, 2018
The Organic Rankine Cycle (ORC) has been proved a promising technique to exploit waste heat from Internal Combustion Engines (ICEs). Waste heat recovery systems have usually been designed based on engine rated working conditions, while engines often ...
Peng Liu, Gequn Shu, Hua Tian, Xuan Wang
doaj   +1 more source

Calculation methodology of working cycle parameters of the diesel engine operating on multicomponent mixture

RURAL DEVELOPMENT 2019, 2009
The article describes the calculation methodology of working cycle parameters of engines operating on multicomponent mixture. The calculation methodology of the state of the working substance is studied as an open thermodynamic system. It enables to develop the working cycle model as sub models of the following processes as gas exchange processes ...
Matijošius, Jonas, Mažeika, Marius, Pukalskas, Saugirdas   +2 more
openaire   +3 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source