Results 121 to 130 of about 1,738,488 (297)

Hybrid modeling for optimizing cell cultivation in mAb production using a small‐scale automated experimental platform

AIChE Journal, EarlyView.
Abstract This work presents the optimization of cell cultivation for monoclonal antibody (mAb) production. We developed a hybrid model describing the effects of multiple process variables on antibody productivity and impurity generation. An automated platform with 12 × 250 mL bioreactors was set up.
Kosuke Nemoto, Yuki Yoshiyama, Mizuki Morisasa, Junshin Iwabuchi, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama   +6 more
wiley   +1 more source

Retracted: An Elastoplastic Softening Damage Model for Hydraulic Fracturing in Soft Coal Seams

Advances in Civil Engineering, 2020
Advances In Civil Engineering
doaj   +1 more source

Real‐time fault detection in multicomponent nuclear‐waste slurries through data fusion of spectroscopic sensors

AIChE Journal, EarlyView.
Abstract Three instruments–Raman spectroscopy, attenuated total reflectance–Fourier transform infrared spectroscopy, and focused beam reflectance measurement–were used to detect sensor faults, mixing faults, and unanticipated chemistry in a system of multicomponent slurries.
Steven H. Crouse, Ronald W. Rousseau, Martha A. Grover   +2 more
wiley   +1 more source

Non‐ureolytic microbially induced carbonate precipitation: Investigating a cleaner biogeotechnical engineering pathway for soil mechanical improvement

The Journal of Engineering
As the world's population grows, there is an increasing need for soil improvement techniques to accommodate construction demands. Current methods, most often, suffer from a high CO2 footprint, leading researchers to resort to biological methods of soil ...
Mohammad Hemayati, Abdolreza Nematollahi, Ehsan Nikooee, Ghassem Habibagahi, Ali Niazi   +4 more
doaj   +1 more source

Trust‐region filter algorithms utilizing Hessian information for gray‐box optimization

AIChE Journal, EarlyView.
Abstract Optimizing industrial processes often involves gray‐box models that couple algebraic glass‐box equations with black‐box components lacking analytic derivatives. Such systems challenge derivative‐based solvers. The classical trust‐region filter (TRF) algorithm provides a robust framework but requires extensive parameter tuning and numerous ...
Gul Hameed, Tao Chen, Antonio del Rio Chanona, Lorenz T. Biegler, Michael Short   +4 more
wiley   +1 more source

Civil engineering aspects of grooving [PDF]

Civil engineering aspects of grooving ...
Miller, A. R.
core   +1 more source

A rational strategy to optimize photodrugs by Molecular Dynamics simulations for killing drug‐resistant Gram‐negative bacteria

AIChE Journal, EarlyView.
Abstract Antimicrobial resistance has become a major threat to human health, particularly for Gram‐negative bacteria such as Acinetobacter baumannii and Klebsiella pneumoniae. Disruption of membrane integrity is regarded as a promising antimicrobial strategy that does not induce distinct drug resistance, while increasing the internalization of drug ...
Lei Hao, Yeonho Song, Cheng Zhang, Yumei Wang, Haoying Ge, Wen Sun, Jingyun Wang, Jun Soo Kim, Xiaojun Peng, Juyoung Yoon, Haidong Li   +10 more
wiley   +1 more source

3D investigation and modeling of the geometric effects on porosity in packed beds

AIChE Journal, EarlyView.
Abstract In porous beds, physical boundaries restrict particle arrangement, leading to inhomogeneous porosity. This paper reports on the porosity profiles that are the result of geometric effects on monodisperse packed beds in cylindrical and cubic arrangements. Special focus is given to the influence of edges and corners in cubic geometries.
Bastian Oldach, Konrad E. R. Boettcher, Alexander S. Sommer‐Behr, Norbert Kockmann   +3 more
wiley   +1 more source

A trust‐region funnel algorithm for gray‐box optimization

AIChE Journal, EarlyView.
Abstract Gray‐box optimization, where parts of optimization problems are represented by algebraic models while others are treated as black‐box models lacking analytic derivatives, remains a challenge. Trust‐region (TR) methods provide a robust framework for gray‐box problems through local reduced models (RMs) for black‐box components, but they are ...
Gul Hameed, Tao Chen, Antonio del Rio Chanona, Lorenz T. Biegler, Michael Short   +4 more
wiley   +1 more source

Stochastic optimization of Power‐to‐Methanol: Production cost sensitivity to process design vs. scheduling

AIChE Journal, EarlyView.
Abstract Under time‐varying electricity prices, the production costs of Power‐to‐X processes with intermediate storage can be reduced by simultaneously optimizing the process unit design and size with their scheduling and operation. However, the production cost sensitivity to optimal process design or scheduling is unclear, especially when several ...
Simone Mucci, Dominik Bongartz
wiley   +1 more source