Results 131 to 140 of about 185,762 (313)
, 2010 Mechanical Engineering students who learn how to design and analyse usually experience complex and /or abstract aspects that they may not be able to fully understand without additional tutorial lessons or further explanations.
Abdulrasool, Salah Mahdi, Mishra, Rakesh
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Effect of cloud computing and vice-versa
, 2021 Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, System Design and Management Program, February, 2021Cataloged from the official version of thesis.
Nwachukwu, Tochi.
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Supply and Demand in the Training of Quantum Software Engineering Workforce
Memoria Investigaciones en IngenieríaQuantum Technologies are experiencing significant growth due to substantial investments made by governments worldwide. These investments aim to enhance global competitiveness in this field and position countries as key players.
Álvaro M. Aparicio-Morales +5 more
doaj +1 more source
, 1997 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The intellectual contribution of this thesis lies within the area of computer supported co-operative work (CSCW), and more specifically, computer supported ...
Perry, Mark Julian
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A shift in technological paradigm : cloud computing to fog computing
, 2018 Over the years, we continue to experience changes in the field of information and technology; these changes are initiated and geared towards addressing the dynamic nature of our environment. The ubiquitous nature of mobile devices has continued to create
Ahmadi, Mohammad (R19695) +3 more
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