Results 121 to 130 of about 15,097,055 (209)

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

In-silico investigation reveals microbial metabolic biomarkers and their regulatory roles in hormone sensitive cancers. [PDF]

J Genet Eng Biotechnol
Anbarasu S, Kacha S, Ramaiah S, Anbarasu A.   +3 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Microvascular blood flow ultrasound imaging with microbubble-based H-Scan technology. [PDF]

Med Biol Eng Comput
Jiang F, Li Y, Cui Y, Jiao Y.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Interpretable prediction of knee joint loading during tennis serves based on GNN-GRU model and layer-wise relevance propagation. [PDF]

Proc Inst Mech Eng H
Pan J, Zhou Z, Gao Z, Chen D, Li F, Baker JS, Gu Y.   +6 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Early-Stage Prototype Assessment of Cost-Effective Non-Intrusive Wearable Device for Instant Home Fetal Movement and Distress Detection: A Pilot Study. [PDF]

Diagnostics (Basel)
Mohamed H, Kathriarachchi SK, Kahatapitiya NS, Silva BN, Kalupahana D, Edirisinghe S, Wijenayake U, Ravichandran NK, Wijesinghe RE.   +8 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology. [PDF]

Nat Biomed Eng
Liu N, Shiravi S, Jin T, Liu J, Zhu Z, Li J, Cheung I, Zhang H, Wang Y, Li Q, Xu Z, Zeng L, Quezada MJ, Villalobos A, Samei Y, Khanna S, Bao S, Wu M, Liang S, Cheng X, Lv Z, Maeng WY, Zhang Y, Luan H, Boppart SA, Huang Y, Zhang Y, Franz CK, Finan JD, Rogers JA.   +29 more
europepmc   +1 more source