Results 61 to 70 of about 7,338,408 (299)

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Experimental modeling methods in Industrial Engineering [PDF]

open access: yesActa Montanistica Slovaca, 2009
Dynamic approaches to a management system of the present industrial practice, forcing businesses to address management issues in-house continuous improvement of production and non-production processes.
Peter Trebuňa
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

INDUSTRIAL ENGINEERING TECHNIQUES AND TOOLKIT ON BASIS OF COMMUNICATION PROCESS SCHEDULING

open access: yesВестник Донского государственного технического университета, 2018
Industrial engineering techniques are total operations and methods for the production or rendering services. The selection of the method and industrial engineering techniques — job shop-type, batch or repetitive — is primarily subject to the industrial ...
Tatyana V. Simonyan   +1 more
doaj  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

INDUSTRIAL ENGINEERING TECHNIQUES AND TOOLKIT ON BASIS OF COMMUNICATION PROCESS SCHEDULING

open access: yesAdvanced Engineering Research, 2011
Industrial engineering techniques are total operations and methods for the production or rendering services. The selection of the method and industrial engineering techniques — job shop-type, batch or repetitive — is primarily subject to the industrial ...
Tatyana V. Simonyan   +1 more
doaj  

Accounting engineering for sustainable development

open access: yesSHS Web of Conferences, 2017
The article deals with the sustainable development of industrial enterprises in Russia, accounting for sustainable industrial growth of the national economy, tools of accounting engineering aimed at creating an information basis of transformation the ...
Sidornya A.
doaj   +1 more source

An engineering design knowledge reuse methodology using process modelling [PDF]

open access: yes, 2007
This paper describes an approach for reusing engineering design knowledge. Many previous design knowledge reuse systems focus exclusively on geometrical data, which is often not applicable in early design stages.
Young, Bob   +9 more
core   +1 more source

Home - About - Disclaimer - Privacy