Results 41 to 50 of about 716,215 (313)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Properties of activated blended cement containing high content of calcined clay

Heliyon, 2018
This paper presents findings of an experimental investigation on sodium sulphate (Na2SO4) activated calcined clay – Portland cement blends in sulphuric acid media.
Marangu J. Mwiti, Thiong'o J. Karanja, Wachira J. Muthengia   +2 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Experimental modeling methods in Industrial Engineering [PDF]

Acta Montanistica Slovaca, 2009
Dynamic approaches to a management system of the present industrial practice, forcing businesses to address management issues in-house continuous improvement of production and non-production processes.
Peter Trebuňa
doaj  

Accounting engineering for sustainable development

SHS Web of Conferences, 2017
The article deals with the sustainable development of industrial enterprises in Russia, accounting for sustainable industrial growth of the national economy, tools of accounting engineering aimed at creating an information basis of transformation the ...
Sidornya A.
doaj   +1 more source

On the use of deep learning and computational fluid dynamics for the estimation of uniform momentum source components of propellers

iScience, 2023
Summary: This article proposes a novel method based on Deep Learning for the resolution of uniform momentum source terms in the Reynolds-Averaged Navier-Stokes equations.
Raúl Martínez-Cuenca, Jaume Luis-Gómez, Sergio Iserte, Sergio Chiva   +3 more
doaj   +1 more source

IMPROVING DISTANCE LEARNING PROCESS IN ENGINEERING EDUCATION USING DESIGN OF EXPERIMENTS: RE-DESIGN OF AN ONLINE INDUSTRIAL ENGINEERING COURSE DURING AND BEYOND THE PANDEMIC COVID-19

, 2022
: This study aims to improve the quality of the learning process in engineering education. The ‎COVID-19 ‎health crisis pushed the scientific community to review teaching practices and reconsider ‎their effectiveness.
Aoula, Es-Saâdia, Ben Souda, Souad, Goumairi, Ouissal   +2 more
core   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Forty years of Computers & Industrial Engineering: A bibliometric analysis [PDF]

, 2017
Computers & Industrial Engineering (CIE) is a leading international journal in the field of industrial engineering, whose first issue was published in 1976.
Christian Cancino, Yasser Dessouky, Dessouky, Y, Cancino, C, Merigó Lindahl, José, Freddy Coronado, Cancino del Castillo, Christian, Coronado Martínez, Freddy, Dessouky, Mohamed, Mohamed Dessouky, Dessouky, M, Merigó, JM, Dessouky, Yasser, Coronado, F, José M. Merigó   +14 more
core   +1 more source