Results 101 to 110 of about 3,277 (223)
The Roles and Utility of Ground Forces in Counterinsurgency and Stability Operations
, 2019 The conflict environment is changing, and—after almost two decades of continuous COIN, stabilisation and counterterrorism missions—government and public opinion in western and allied countries are unlikely to support continued large-scale or long ...
Kilcullen, David ; https://orcid.org/
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Ett berömt misslyckande - En fallstudie av Operation Market Garden ur ett fältarbetsperspektiv
, 2018 Operation Market Garden is famous for its failure, although before its execution, all signs pointed to an imminent Allied victory. As well as being outnumbered in both men and weapons the Germans were also disorganized due to previous defeats. The reason
Rosgren, Fredrik
core
Contributions of Women in Agricultural Engineering and Technology
Advancement of science and technology in different fields has created new vistas for progress and well-being of humankind. Agriculture is one such field that continues to benefit from new knowledge and technological breakthroughs.
Dr Falguni Thakar
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
, 2014 A research survey was undertaken to study the ‘Scientists’ Purpose of Visiting E‐Journal Sites’. The geographic boundary of this research study consists of 16 prominent aerospace organizations of Bangalore.
Guruprasad, R, Marimuthu, P
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2010 Open pit mine operations are complex businesses that demand a constant assessment of risk. This is because the value of a mine project is typically influenced by many underlying economic and physical uncertainties, such as metal prices, metal grades ...
Tipe, Luis Alberto Martinez
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source