Results 181 to 190 of about 250,405 (253)

The unreliability of estimated release dates in hospital drug shortage management: A case study of hospital pharmacy operations during the COVID-19 pandemic. [PDF]

PLoS One
Chicoine N, Griffin J.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Incidence of Alpha-Gal IgE Sensitization in 3000 Military Personnel, Assessing Sex, Race, Installation, and Occupational Impacts. [PDF]

J Clin Med
Ching SJ, Susi A, Ailsworth SM, Workman LJ, Platts-Mills TAE, Wilson JM, Nylund CM.   +6 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The cyber-enhanced tank: a novel concept for increased realism and multi-modal monitoring in tank based finfish aquaculture research. [PDF]

Front Robot AI
Voskakis D, Føre M, Svendsen E, Liland AP, Rey Planellas S, Eguiraun H, Klebert P.   +6 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Student Perspectives on Marketing the Podiatry Profession and Course Promotion: A Mixed Methods Study. [PDF]

J Foot Ankle Res
Kaminski MR, Robinson C, Whittaker GA, Ho M, Bonanno DR, Munteanu SE, Dollinger M, Kazantzis S, Li X, Causby RS, Frecklington M, Walmsley S, Chuter V, Casey SL, Cotchett M.   +14 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A gamification training system designed according to a mental model structure: A case study of universal robots. [PDF]

Sci Rep
Sriviboon Y, Jiamsanguanwong A, Chutima P, Kittithreerapronchai O.   +3 more
europepmc   +1 more source

The Air Force and Twenty-First-Century Conflicts: Dysfunctional or Dynamic? [PDF]

, 2010
Dunlap, Charles J., Jr.
core   +1 more source