Results 301 to 310 of about 24,595,607 (343)

Meteorological data implications modeling on evapotranspiration variability in arid and semi-arid zones in Saudi Arabia using hybrid metaheuristic. [PDF]

Sci Rep
Noureddine ON, Mohamed S, El Amine C, Alzaed A, Gedfew MA, Ghoneim SSM, Hussein EE.   +6 more
europepmc   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Interlayer engineering of lattice dynamics and elastic constants of 2D layered nanomaterials under pressure. [PDF]

Nat Commun
Du G, Zhao L, Li S, Huang J, Fang S, Han W, Li J, Du Y, Ming J, Zhang T, Zhang J, Kang J, Li X, Xu W, Chen Y.   +14 more
europepmc   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Engineering a cleaved, prefusion-stabilized influenza B virus hemagglutinin by identification and locking of all six pH-switches

Jarek Juraszek, Fin Milder, Xiaodi Yu, Sven Blokland, Daan van Overveld, Pravien Abeywickrema, Sem Tamara, Sujata Sharma, Lucy Rutten, Mark J. G. Bakkers, Johannes P. M. Langedijk   +10 more
openalex   +1 more source

Towards a Psychologically Realist, Culturally Responsive Approach to Engineering Ethics in Global Contexts. [PDF]

Sci Eng Ethics
Clancy RF, Zhu Q, Streiner S, Gammon A, Thorpe R.   +4 more
europepmc   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Engineering of a compact, high-fidelity EbCas12a variant that can be packaged with its crRNA into an all-in-one AAV vector delivery system

Hongjian Wang, Jin Zhou, Jun Lei, Guosheng Mo, Yankang Wu, Huan Liu, Ziyan Pang, Mingkun Du, Zihao Zhou, Chonil Paek, Zaiqiao Sun, Yongshun Chen, Yan Wang, Peng Chen, Lei Yin   +14 more
openalex   +2 more sources

A Multi-Strategy Adaptive Coati Optimization Algorithm for Constrained Optimization Engineering Design Problems. [PDF]

Biomimetics (Basel)
Wu X, Ding Y, Wang L, Zhang H.
europepmc   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source