Results 41 to 50 of about 1,989,992 (317)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

0.74 W Broadband Degenerate Femtosecond MgO-Doped Periodically Poled Lithium Niobate (MgO: PPLN) Optical Parametric Oscillator at 2056 nm

Photonics
The degenerate optical parametric oscillator (OPO) is demonstrated to generate high-power, broadband mid-infrared MgO-doped periodically poled lithium niobate (MgO:PPLN) femtosecond laser at 151 MHz, synchronously pumped by a commercial Kerr-lens mode ...
Yuxiang Zhao, Bobo Wang, Jinfang Yang, Taotao He, Hao Xu, Xue Qiu, Zhong Dong, Weijun Ling   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Effects of roughness and resonant-mode engineering in all-dielectric metasurfaces

Nanophotonics, 2020
The development of all-dielectric metasurfaces vigorously prompts the applications of optical metasurfaces for the visible and near-IR light range. Compared to IR or longer wavelength light, visible and near-IR light have shorter wavelengths. As a result,
Yang Hao, Liu He, Song Boxiang, Li Yuanrui, Meng Deming, Chen Buyun, Hu Pan, Wang Yunxiang, Ou Tse-Hsien, Povinelli Michelle L., Wu Wei   +10 more
doaj   +1 more source

Conceptual approaches to assessment and allocation of unused lands for organic agriculture projects

Новые технологии, 2021
The purpose of the research is to develop a scientifically based system for assessing and allocating unused agricultural lands for the creation of organic agriculture projects. The Methods.
V. V. Borodychev, V. A. Shevchenko, M. N. Lytov   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Non-invasive intravoxel incoherent motion MRI in prediction of histopathological response to neoadjuvant chemotherapy and survival outcome in osteosarcoma at the time of diagnosis

Journal of Translational Medicine, 2022
Background Early prediction of response to neoadjuvant chemotherapy (NACT) is important to aid personalized treatment in osteosarcoma. Diffusion-weighted Intravoxel Incoherent Motion (IVIM) MRI was used to evaluate the predictive value for response to ...
Esha Baidya Kayal, Sameer Bakhshi, Devasenathipathy Kandasamy, Mehar Chand Sharma, Shah Alam Khan, Venkatesan Sampath Kumar, Kedar Khare, Raju Sharma, Amit Mehndiratta   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Offering an Entrepreneurship Course to All Engineering Students: Lessons Learned from ING2030 in Puc-Chile

, 2021
All rights reserved.Entrepreneurial learning experiences have become one of the key aspects of the state of the art in engineering education. As such, technology-focused entrepreneurship courses have been incorporated to engineering curricula — both in ...
Hilliger Carrasco, Isabel, Baier Aranda, Jorge Andrés, Fleet, Constance, Melian, Constanza, Perez Sanagustin, Maria Del Mar   +4 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source