Results 71 to 80 of about 1,534,548 (227)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The double capstan as a position controller.

, 1978
Thesis (B.S.)--Massachusetts Institute of Technology, Dept.
Freeman, Janet Elizabeth
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The effects of secondary flows on the heat transfer to turbine nozzle endwall and rotor shroud.

, 1979
Thesis (Sc.D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1979.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING.Vita.Includes bibliographical references.Sc ...
Nebo, Anthony Chibuzo
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mechanics of bending nonwoven fabrics.

, 1979
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1979.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING.Vita.Includes bibliographical references.Ph ...
Lee, Shaw Ming
core  

Collaborative Reverse Engineering Design Experiment Using PLM Solutions [PDF]

, 2011
The current climate of economic competition forces businesses to adapt to the expectations of their customers. To achieve this, in spite of the increasing complexity of mechanical systems, it becomes necessary, amongst other things, to reduce design time.
AOUSSAT, Améziane, VERON, Philippe, SEGONDS, Frederic, MARANZANA, Nicolas   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Application of a variable volume mold to the shrinkage control of injection molded parts.

, 1978
Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1978.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING.Includes bibliographical references.B ...
Halstead, Whitfield Gardner
core  

Proceedings of China modern logistics engineering: inheritance, wisdom, innovation and cooperation

, 2015
Proceedings of China Modern Logistics Engineering covers nearly all areas of logistics engineering technology, focusing on the latest findings and the following theoretical aspects: Logistics Systems and Management Research; Green Logistics and Emergency
Logistics Engineering Institution CMES
core   +1 more source