Results 261 to 270 of about 5,500,511 (357)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Correction: Yuan et al. Machine Learning Prediction Models to Evaluate the Strength of Recycled Aggregate Concrete. <i>Materials</i> 2022, <i>15</i>, 2823. [PDF]

Materials (Basel)
Yuan X, Tian Y, Ahmad W, Ahmad A, Usanova KI, Mohamed AM, Khallaf R.   +6 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Correction: Unmanned aerial vehicle payload technology applications in agriculture and other low altitude scenarios: a review. [PDF]

Front Plant Sci
Yao W, Liu C, Liu Y, Zheng Q, Wang J, Yu H, Chen C, Guo S.   +7 more
europepmc   +1 more source

OPTIMAL RISK-BASED DESIGN OF CHAO PHRAYA RIVER FLOOD CONTROL SYSTEM FOR BANGKOK [PDF]

, 1999
Kitpaisalsakul, T., Lecturer, Department of Water Resources Engineering, Faculty of Engineering, Chulalongkorn University, Professor, Water Engineering and Management Program, School of Civil Engineering, Asian Institute of Technology, Tingsanchali, T.   +3 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correction: Yang et al. Engineering n-Type and p-Type BiOI Nanosheets: Influence of Mannitol on Semiconductor Behavior and Photocatalytic Activity. Nanomaterials 2024, 14, 2048. [PDF]

Nanomaterials (Basel)
Yang S, Li W, Li K, Huang P, Zhuo Y, Liu K, Yang Z, Han D.   +7 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Retraction notice to "Experimental investigations of dual functional substrate integrated waveguide antenna with enhanced directivity for 5G mobile communications" [Heliyon 10 (2024) e36929]. [PDF]

Heliyon
Sathishkumar N, Palanisamy S, Natarajan R, V R A, Ouahada K, Hamam H.   +5 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source