Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Research on Thermal Insulation and Durability of Bio-Based Thermal Insulation Materials and Its Prospect of Engineering Application. [PDF]
Luo S +5 more
europepmc +1 more source
Non-Reciprocal Elasticity in the Application of Equivalence Principle in Engineering Fluid Mechanics
huanyu huangfu +2 more
openalex +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Aiming at the problems of complex deformation mechanisms of old buttress dams and insufficient accuracy of traditional prediction models, this paper proposed an improved Transformer deformation prediction model based on the whale optimization algorithm ...
JU Hairong +3 more
doaj
Multi-Material Extrusion-Based 3D Printing of Hybrid Scaffolds for Tissue Engineering Application. [PDF]
Abramov A, Sulkhanov Y, Menshutina N.
europepmc +1 more source
Engineering application of vacuum preloading combined with electroosmosis technique in excavation of soft soil on complex terrain. [PDF]
Sun Z, Geng J, Wei G, Li W.
europepmc +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Porous Curdlan-Whey Protein Isolate Scaffolds Obtained by Combined Method for Cartilage Tissue Engineering Application. [PDF]
Hnydka A +3 more
europepmc +1 more source

