Results 41 to 50 of about 4,234,556 (345)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Comparative study of design: application to Engineering Design [PDF]

, 2005
A recent exploratory study examines design processes across domains and compares them. This is achieved through a series of interdisciplinary, participative workshops.
Blackwell, A., Bucciarelli, L., Clarkson, P. J., Earl, C., Eckert, C., Knight, T., Macmillan, S., Stacey, M., Whitney, D.   +8 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Stability of Boats: A Science, Technology, Engineering, and Mathematics (STEM) Exercise [PDF]

, 2015
In what might be called genuine Science, Technology, Engineering, and Mathematics (STEM), an engineering construct subject to well-understood physical principles is analyzed mathematically to yield predicted behavior.
Rublein, G.
core   +1 more source

Active involvement of students in co-curriculum (sports) versus generic skills [PDF]

, 2017
The active involvement of students in sports activities is viewed from different levels of achievement beginning with the national representation of the residential colleges, faculties, and universities in prestigious sporting events at international ...
Azmir, N. A., Ismail, A. E., Ismon, M., Kasron, M. Z., Lau, S. F., Madlan, M. A., Yahya, M. N., Zainulabidin, M. H., Zaman, I.   +8 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Application Research of SCR Denitration in Building Gas Distributed Energy System

发电技术, 2018
With the deepening contradiction between energy and environment, the energy industry is transforming from traditional energy to clean energy. Therefore, more and more attention will be paid to high efficiency and low carbon natural gas distributed energy
Xueqin WANG, Wenkun ZHU, Jingjing XU, Ting JIANG, Yongfeng HU   +4 more
doaj   +1 more source

Advanced Cloud Privacy Threat Modeling

, 2016
Privacy-preservation for sensitive data has become a challenging issue in cloud computing. Threat modeling as a part of requirements engineering in secure software development provides a structured approach for identifying attacks and proposing ...
Gholami, Ali, Laure, Erwin
core   +1 more source