Results 51 to 60 of about 4,234,556 (345)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Application Of Fuzzy Mathematics Methods To Processing Geometric Parameters Of Degradation Of Building Structures [PDF]

, 2018
The aim of research is formalization of the expert experience, which is used in processing geometric parameters of building structure degradation, using fuzzy mathematics.
Kartavykh, S. (Serhii), Nasikovskyi, O. (Oleksandr), Terenchuk, S. (Svitlana), Yeremenko, B. (Bohdan)   +3 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The preparation and performance research and application of high performance steel fiber reinforced concrete in deep and large freezing shaft

Materials Research Express
To address the issues of temperature cracks and water leakage in the support structure of deep and large freezing shafts in western China, high-performance concrete incorporating steel fibers and fly ash was proposed as a wall construction material ...
Jiabao Hu, Zhishu Yao, Yongjie Xu, Rui Wang, Kun Hu   +4 more
doaj   +1 more source

Cloud-Based Collaborative 3D Modeling to Train Engineers for the Industry 4.0 [PDF]

, 2019
In the present study, Autodesk Fusion 360 software (which includes the A360 environment) is used to train engineering students for the demands of the industry 4.0.
de la Torre Cantero, Jorge, López Chao, Vicente Adrián, Melián Díaz, Dámari, Saorín, José Luis   +3 more
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Multi-Field Coupling Models of Coal and Gas and Their Engineering Applications to CBM in Deep Seams: A Review

Energies
In the process of deep coal seam mining, the problem of coal–gas compound disasters is increasingly prominent, with the safe and efficient extraction of gas serving as the key to disaster reduction.
Xingying Ma, Aitao Zhou, Xiaoyu Cheng, Cheng Cheng, Wei Zhao   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Composition Optimization and Field Application of Colored Emulsified Asphalt Seal Mixture

Frontiers in Materials, 2020
A uniform test design method was used to investigate the storage stability, wear resistance performance, anti-slide performance, and color durability of a colored emulsified asphalt seal mixture (CEASM).
Zhilin Sun, Zhihang Zhu, Junhui Zhang, Chao Wu   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source