Results 81 to 90 of about 4,234,556 (345)

Optimization and application of sand bailing technology for coalbed methane horizontal wells

open access: yesMeitian dizhi yu kantan
Objective and Methods Coalbed methane (CBM) horizontal wells face challenges such as sand accumulation in completion strings, pipe wall scaling, and pump sticking, leading to declined CBM production or shutdown of these wells.
Fei ZHANG   +10 more
doaj   +1 more source

Technique for Evaluating Multiple Probability Occurrences /TEMPO/ [PDF]

open access: yes, 1970
Technique is described for adjustment of engineering response information by broadening the application of statistical subjective stimuli theory. The study is specifically concerned with a mathematical evaluation of the expected probability of relative ...
Mezzacappa, M. A.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Genetic engineering possibilities for CELSS: A bibliography and summary of techniques [PDF]

open access: yes
A bibliography of the most useful techniques employed in genetic engineering of higher plants, bacteria associated with plants, and plant cell cultures is provided. A resume of state-of-the-art genetic engineering of plants and bacteria is presented. The
Johnson, E. J.
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Research on Optimization Design and Application for 1 000 MW Power Plant Under Current Stricter EIA Standard

open access: yes南方能源建设, 2019
[Introduction] The initial investment and operation cost of the power plant are significantly increased after the ultra-low emission configuration is selected for the project of new coal-fired power units.
HUANG Haihua, WU Afeng
doaj   +1 more source

Application Experiences of NASTRAN Thermal Analysis in Engineering [PDF]

open access: yes
The application of the thermal analysis phase of NASTRAN in engineering is described. Some illustrative samples are presented to demonstrate the applicability and limitation of NASTRAN thermal analysis capability.
Go, J. C. D.
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Comprehensive Adaptive Enterprise Optimization Algorithm and Its Engineering Applications

open access: yesBiomimetics
In this study, a brand-new algorithm called the Comprehensive Adaptive Enterprise Development Optimizer (CAED) is proposed to overcome the drawbacks of the Enterprise Development (ED) algorithm in complex optimization tasks.
Shuxin Wang   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

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