Results 191 to 200 of about 1,316,802 (291)

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai, Shriarjun Shastry, Morgan R. Hurst, Arianna Minzoni, Eduardo Barbieri, Luke Remmler, Eugene N. Muratov, Michael A. Daniele, Stefano Menegatti, Alexander Tropsha   +9 more
wiley   +1 more source

Dilatant Failure States for Drained Triaxial Compression of Some Geomaterials. [PDF]

Materials (Basel)
Szypcio Z, Dołżyk-Szypcio K, Gabryś K, Sas W.   +3 more
europepmc   +1 more source

Influence of Zn2+ and Oxygen Supply on Malic Acid Production and Growth of Aspergillus oryzae

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Malic acid is a valuable platform chemical traditionally derived from fossil‐based resources. Microbial cultivation with Aspergillus oryzae offers a sustainable alternative based on renewable feedstocks. In this study, a well‐established minimal medium for malic acid production, commonly used in previous research to ensure reproducibility, was
Lukas Hartmann, Anke Neumann, Dirk Holtmann, Katrin Ochsenreither   +3 more
wiley   +1 more source

Remote Tower Air Traffic Controller Multimodal Fatigue Detection. [PDF]

Sensors (Basel)
Pan W, Song D, Liang R, Yin Z, Han B.
europepmc   +1 more source

Development of Raman Spectroscopy and Machine Learning Methods for Protein Aggregate Quantification: Application to BSA in Chromatographic Processes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein aggregation poses a significant risk to biopharmaceutical product quality, as even minor amounts of oligomeric species can compromise efficacy and safety. Rapid and reliable detection of protein aggregates thus remains a major challenge in biopharmaceutical manufacturing.
Jakob Heyer‐Müller, Robin Schiemer, Lars Robbel, Michael Schmitt, Jürgen Hubbuch   +4 more
wiley   +1 more source

Education Reform using Common Career Selective Programme (CCSP) to Promote Education-for-All (EFA). [PDF]

F1000Res
Agyemang F, Woode B, Kofi Fosuhene S, Browne Klutse NA, Kojo Nyarko A, Oku Asamoah S, Antwi Agyei B.   +6 more
europepmc   +1 more source

High Yield Branched Puromycin Linker Design Enables Efficient cDNA Display and Chemical Modification of Peptides

Biotechnology and Bioengineering, EarlyView.
A novel puromycin linker for cDNA display was synthesized via SPAAC reaction. Its functionality was confirmed by recovering intact DNA after selection against EpCAM. The system also enabled the verification of bicyclic peptides during display, demonstrating its utility for constructing and screening structurally complex peptide libraries.
Simon Schneider, Melanie Boll, Matthias Eder, Ann‐Christin Eder   +3 more
wiley   +1 more source

Augmented reality in engineering education: Strategic design and evidence-based results. [PDF]

PLoS One
Donaire S, Barraza R, Martínez-Pagán P, Martínez-Segura MA, Álvarez L, Yepes-Bellver L, Yepes V.   +6 more
europepmc   +1 more source

Gaussian Processes for Predictive QSAR Modeling of Chromatographic Processes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chromatography is a key unit operation in the biopharmaceutical manufacturing process used for protein purification and polishing. Design and optimization of these processes are resource‐intensive resulting from the complex combinatorial design space.
Harini Narayanan, Douglas Nolan, Lijuan Li, Edward King, Andrew Fiordalis, David Benjamin Nickel, George Parks, J. Christopher Love   +7 more
wiley   +1 more source

Macro-micro deformation characteristics of undisturbed loess under different hydraulic paths. [PDF]

Sci Rep
Fu W, Shao S, She F, Luo A, Zhao Z.
europepmc   +1 more source