Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5
ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo +3 more
wiley +1 more source
Sustainable Stabilization of Silty Sand Using Recycled Industrial Polymer Reinforcement with a Hybrid Lime-Cement Binder. [PDF]
Lounas A +3 more
europepmc +1 more source
Thermodynamic Evaluation of Dual Substrate Growth
ABSTRACT Various C₁–C₂ compounds are increasingly available through electrochemical reduction of CO2. Although not always suitable as a sole substrate, these compounds can supplement a primary substrate like glucose to enhance microbial growth. Yet, the mechanisms underlying the effects of dual substrate consumption on growth rate and growth yield ...
Marit A. Verheijen +3 more
wiley +1 more source
Effect of graphene nanoplatelets on the behaviour of cementitious compounds: an experimental investigation. [PDF]
Anitha Selvasofia SD +6 more
europepmc +1 more source
Asymmetric Dialysis: Truly Unified and Simultaneous Single‐Pass Concentration and Buffer Exchange
Asymmetric dialysis, a novel one‐step continuous process combining ultrafiltration and diafiltration, achieves high product concentrations (up to 200 g/L) with low pressures and reduces buffer consumption by 75% compared to conventional methods. This sustainable, low‐cost technology demonstrates significant potential for integration into continuous ...
Ujwal Patil +3 more
wiley +1 more source
A dataset of wind tunnel measurements for a laboratory demonstrator of a small ducted wind turbine equipped with passive flow control devices. [PDF]
Coșoiu CI +3 more
europepmc +1 more source
Engineered B7‐H3 Binding in Modular Gp2 Miniproteins
ABSTRACT B7‐H3, an important immune checkpoint modulator of T‐cell function, is a tumor vasculature biomarker and is overexpressed in a variety of cancers. Its expression is associated with tumor growth, metastasis, and poor clinical prognosis, which makes B7‐H3 an appealing target for diagnostics and therapeutics.
Abbigael Harthorn +5 more
wiley +1 more source
Particle contact evolution: A precursor mechanism for earthquake-induced liquefaction prior to pore-pressure buildup. [PDF]
Zheng H +10 more
europepmc +1 more source
ABSTRACT In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically complex. This study presents a modular mechanistic model of the IVT process to advance scientific understanding ...
Keqi Wang +12 more
wiley +1 more source
Mapping mismanaged plastic waste in Indonesia: subdistrict-level analysis through material flow from sources to the environment. [PDF]
Ramadan AH +3 more
europepmc +1 more source

