Results 91 to 100 of about 12,057,244 (369)
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Valuing Knowledge Management Impact on Engineering Design Activities [PDF]
Knowledge Management Systems (KMS) have been developed in Engineering Designactivities in order to improve the productivity of these activities. Nevertheless it is still verydifficult to identify the impact of such Systems on the Engineering Design ...
Aurélie Dudezert, Mickaël Gardoni
core
RWU Holds Steel “Topping-Off” Ceremony for Engineering, Computing & Construction Management Labs [PDF]
, 2018 Roger Williams University on Monday held a steel “topping-off” ceremony, marking completion of the steel framework for a laboratories building for RWU’s School of Engineering, Computing and Construction ...
Fitzpatrick, Edward
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Research on the Intelligent Construction and Development of Bridge Engineering Safety Management [PDF]
E3S Web of ConferencesTo deeply explore the development path of intelligent construction of bridge engineering safety management under the background of intelligent construction in China’s construction industry, based on the technical characteristics of bridge engineering and
Zhang Siyuan, Yu Bo, Li Ruipu, Wan Yang
doaj +1 more source
Creativity in Mass-Education Contexts [PDF]
, 2006 This paper discusses a learning framework (working title: ‘fog framework’) that has been developed in response to the challenge of teaching creative subjects in a mass-education context.
Anusas, M.
core
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Application of Deep Learning in Civil Engineering Management. [PDF]
Comput Intell Neurosci, 2022 Zhao H.
europepmc +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source