Results 111 to 120 of about 12,057,244 (369)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

open access: yesMolecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban   +12 more
wiley   +1 more source

Construction and Application of Digital Asset Platform for Hydropower Engineering

open access: yesRenmin Zhujiang, 2022
The development of informatization and digitization of hydropower engineering is exposed to problems such as inconsistent data standards,uneven data quality,scattered data storage,weak correlation between data,and difficult data sharing.By referring to ...
JIA Yuhao
doaj  

Defensive Routines in Engineering Managers and Non-Engineering Managers — A Case Analysis

open access: yesInternational Journal of Engineering Business Management, 2015
There is a perception that engineers experience challenges in areas such as communication, conflict resolution, and leadership. Defensive routines are actions implemented as a result of being in an embarrassing or threatening situation. This research uses a case study approach to measure whether defensive routines are more common in engineering ...
Riley, Tyria, Cudney, Elizabeth R.
openaire   +4 more sources

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

Town of New Durham Stormwater Management & Erosion Control Project [PDF]

open access: yes, 2010
Appledore Engineering worked with the New Durham Planning Board to develop a stormwater management and erosion control ordinance and to adopt complimentary improvements to the town’s site plan review and subdivision ...
Town of Durham
core   +2 more sources

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