Results 131 to 140 of about 11,840,051 (392)

Integrated Information Management for TESLA [PDF]

open access: yesarXiv, 2003
Next-generation projects in High Energy Physics will reach again a new dimension of complexity. Information management has to ensure an efficient and economic information flow within the collaborations, offering world-wide up-to-date information access to the collaborators as one condition for successful projects.
arxiv  

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

Towards Dependable Change Management and Traceability for Global Software Development [PDF]

open access: yesarXiv, 2016
This paper reports on our definition of guidelines for managing global software development (GSD) that implements the specific practice - manage requirements changes - of the Capability Maturity Model Integration (CMMI) Level 2. The guidelines present a model for change management and traceability that supports the implementation of the specific CMMI ...
arxiv  

Management issues in systems engineering [PDF]

open access: yes
When applied to a system, the doctrine of successive refinement is a divide-and-conquer strategy. Complex systems are sucessively divided into pieces that are less complex, until they are simple enough to be conquered.
Aster, Robert   +7 more
core   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

An Ontological Learning Management System [PDF]

open access: yesarXiv, 2017
The current learning systems typically lack the level of metacognitive awareness, self-directed learning, and time management skills. Most of the ontologically based learning management systems are in the proposed phase and those which are developed do not provide the necessary path guidance for proper learning.
arxiv  

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

open access: yesMolecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan   +6 more
wiley   +1 more source

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