Results 81 to 90 of about 1,787,163 (286)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A diffractive element-based chromatic confocal thickness measurement device and thickness correction method

iScience
Summary: Wafer thickness is a critical parameter in semiconductor manufacturing, influencing production costs, and chip performance. Traditional measurement methods using clamping devices often introduce errors due to uneven positioning or unstable ...
Zhisong Li, Zhenwei Zhang, Keke Liu, Haojie Zhang, Yong Kong, Xin Ye, Xin Tang   +6 more
doaj   +1 more source

Gendered patterns in the construction of physics identity from motivational factors

Physical Review Physics Education Research, 2019
Students’ intentions to persevere and their career choices in science, technology, engineering, and math fields can be impacted by their physics identities. Women are severely underrepresented at all levels in physics and engineering.
Z. Yasemin Kalender, Emily Marshman, Christian D. Schunn, Timothy J. Nokes-Malach, Chandralekha Singh   +4 more
doaj   +1 more source

Open educational resources, cultural artifacts, conception’s physics teachers for engineering analysis of two case studies

Góndola, Enseñanza y Aprendizaje de las Ciencias, 2016
The research attempts to answer questions such as: What are the concepts of physics teachers who work in the engineering faculty on the use of Open Educational Resources (OER)?
Oscar Jardey Suárez
doaj   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

How Quantum Computers Fail: Quantum Codes, Correlations in Physical Systems, and Noise Accumulation [PDF]

, 2011
The feasibility of computationally superior quantum computers is one of the most exciting and clear-cut scientific questions of our time. The question touches on fundamental issues regarding probability, physics, and computability, as well as on exciting
Kalai, Gil
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Characterizing the epistemological development of physics majors

Physical Review Special Topics. Physics Education Research, 2009
Students in introductory physics courses are likely to have views about physics that differ from those of experts. However, students who continue to study physics eventually become experts themselves.
Elizabeth Gire, Barbara Jones, Edward Price   +2 more
doaj   +2 more sources

First-Year Mathematics and Its Application to Science: Evidence of Transfer of Learning to Physics and Engineering

Education Sciences, 2018
Transfer of mathematical learning to science is seen as critical to the development of education and industrial societies, yet it is rarely interrogated in applied research.
Yoshitaka Nakakoji, Rachel Wilson
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source